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The Scientific World Journal
Volume 2013, Article ID 890187, 6 pages
http://dx.doi.org/10.1155/2013/890187
Research Article

NHCs Catalyzed Hydrophosphonylation of -Ketoesters and -Trifluoromethyl Ketones

Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan and School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang 832000, China

Received 17 August 2013; Accepted 2 October 2013

Academic Editors: T. Gajda and R. P. Herrera

Copyright © 2013 Lin He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

N-Heterocyclic carbenes catalyzed hydrophosphonylation reaction of α-ketoesters and α-trifluoromethyl ketones was developed. Under the catalysis of 10 mol% IPr, α-ketoesters or α-trifluoromethyl ketones reacted with dialkyl phosphites to provide quaternary α-hydroxyphosphonates in good to excellent yield.