Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2013 (2013), Article ID 891581, 7 pages
http://dx.doi.org/10.1155/2013/891581
Research Article

Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China

1Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
2Department of Neurology, NO 202 Hospital of People’s Liberation Army of China, Shenyang 110001, China
3Department of Neurology, Jinqiu Hospital of China Liaoning Province, Shenyang 110001, China

Received 30 June 2013; Accepted 30 July 2013

Academic Editors: W. Hall and R. I. Sakakibara

Copyright © 2013 Yingjie Dai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Bonita, S. Mendis, T. Truelsen, J. Bogousslavsky, J. Toole, and F. Yatsu, “The global stroke initiative,” Lancet Neurology, vol. 3, no. 7, pp. 391–393, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Liu, B. Wu, W.-Z. Wang, L.-M. Lee, S.-H. Zhang, and L.-Z. Kong, “Stroke in China: epidemiology, prevention, and management strategies,” Lancet Neurology, vol. 6, no. 5, pp. 456–464, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. H. P. Adams Jr., B. H. Bendixen, L. J. Kappelle et al., “Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial,” Stroke, vol. 24, no. 1, pp. 35–41, 1993. View at Google Scholar · View at Scopus
  4. L. B. Goldstein, R. Adams, M. J. Alberts et al., “Primary prevention of ischemic stroke. A guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council,” Stroke, vol. 37, no. 6, pp. 1583–1633, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. J. P. Casas, A. D. Hingorani, L. E. Bautista, and P. Sharma, “Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18 000 cases and 58 000 controls,” Archives of Neurology, vol. 61, no. 11, pp. 1652–1661, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Ariyaratnam, J. P. Casas, J. Whittaker, L. Smeeth, A. D. Hingorani, and P. Sharma, “Genetics of ischaemic stroke among persons of non-European descent: a meta-analysis of eight genes involving ~ 32,500 individuals,” PLoS Medicine, vol. 4, no. 4, pp. 728–736, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. J. M. Staton, M. S. Sayer, G. J. Hankey et al., “Association between phosphodiesterase 4D gene and ischaemic stroke,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 77, no. 9, pp. 1067–1069, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Helgadottir, A. Manolescu, G. Thorleifsson et al., “The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke,” Nature Genetics, vol. 36, no. 3, pp. 233–239, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. U. Förstermann and W. C. Sessa, “Nitric oxide synthases: regulation and function,” European Heart Journal, vol. 33, no. 7, pp. 829–837, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Berger, F. Stögbauer, M. Stoll et al., “The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies,” Human Genetics, vol. 121, no. 2, pp. 169–178, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Morishita, M. Tsutsui, H. Shimokawa et al., “Vasculoprotective roles of neuronal nitric oxide synthase,” The FASEB Journal, vol. 16, no. 14, pp. 1994–1996, 2002. View at Google Scholar · View at Scopus
  12. V. W. T. Liu and P. L. Huang, “Cardiovascular roles of nitric oxide: a review of insights from nitric oxide synthase gene disrupted mice,” Cardiovascular Research, vol. 77, no. 1, pp. 19–29, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Tsutsui, “Neuronal nitric oxide synthase as a novel anti-atherogenic factor,” Journal of atherosclerosis and thrombosis, vol. 11, no. 2, pp. 41–48, 2004. View at Google Scholar · View at Scopus
  14. P. J. Kuhlencordt, S. Hötten, J. Schödel et al., “Atheroprotective effects of neuronal nitric oxide synthase in apolipoprotein E knockout mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 7, pp. 1539–1544, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. M. D. Seddon, P. J. Chowienczyk, S. E. Brett, B. Casadei, and A. M. Shah, “Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo,” Circulation, vol. 117, no. 15, pp. 1991–1996, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Toda, K. Ayajiki, and T. Okamura, “Cerebral blood flow regulation by nitric oxide: recent advances,” Pharmacological Reviews, vol. 61, no. 1, pp. 62–97, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Toda, K. Ayajiki, and T. Okamura, “Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase,” Journal of Hypertension, vol. 27, no. 10, pp. 1929–1940, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. W. T. Talman and D. Nitschke Dragon, “Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension,” Brain Research, vol. 1139, no. 1, pp. 126–132, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. Z. Huang, P. L. Huang, N. Panahian, T. Dalkara, M. C. Fishman, and M. A. Moskowitz, “Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase,” Science, vol. 265, no. 5180, pp. 1883–1885, 1994. View at Google Scholar · View at Scopus
  20. Z. Huang, P. L. Huang, J. Ma et al., “Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine,” Journal of Cerebral Blood Flow and Metabolism, vol. 16, no. 5, pp. 981–987, 1996. View at Google Scholar · View at Scopus
  21. L. Zhou and D.-Y. Zhu, “Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications,” Nitric Oxide, vol. 20, no. 4, pp. 223–230, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Manso, T. Krug, J. Sobral et al., “Variants within the nitric oxide synthase 1 gene are associated with stroke susceptibility,” Atherosclerosis, vol. 220, no. 2, pp. 443–448, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Bujalkova, K. Zavodna, T. Krivulcik et al., “Multiplex SNaPshot genotyping for detecting loss of heterozygosity in the mismatch-repair genes MLH1 and MSH2 in microsatellite-unstable tumors,” Clinical Chemistry, vol. 54, no. 11, pp. 1844–1854, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Yamaguchi, Y. Yamada, N. Metoki et al., “Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis,” International Journal of Molecular Medicine, vol. 18, no. 5, pp. 871–883, 2006. View at Google Scholar · View at Scopus
  25. J. Zhao, Z. He, S. Ma, and L. Li, “Association of ALOX15 gene polymorphism with ischemic stroke in Northern Chinese Han population,” Journal of Molecular Neuroscience, vol. 47, no. 3, pp. 458–464, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Deng, G. Zhu, F. Liu et al., “CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 34, no. 4, pp. 664–668, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. O. Lekontseva, S. Chakrabarti, Y. Jiang, C. C. Cheung, and S. T. Davidge, “Role of neuronal nitric-oxide synthase in estrogen-induced relaxation in rat resistance arteries,” Journal of Pharmacology and Experimental Therapeutics, vol. 339, no. 2, pp. 367–375, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. R. W. Morris and N. L. Kaplan, “On the advantage of haplotype analysis in the presence of multiple disease susceptibility alleles,” Genetic Epidemiology, vol. 23, no. 3, pp. 221–233, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. J. N. Wilcox, R. R. Subramanian, C. L. Sundell et al., “Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 17, no. 11, pp. 2479–2488, 1997. View at Google Scholar · View at Scopus
  30. J. Schödel, P. Padmapriya, A. Marx, P. L. Huang, G. Ertl, and P. J. Kuhlencordt, “Expression of neuronal nitric oxide synthase splice variants in atherosclerotic plaques of apoE knockout mice,” Atherosclerosis, vol. 206, no. 2, pp. 383–389, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Chakrabarti, C. K. Chan, Y. Jiang, and S. T. Davidge, “Neuronal nitric oxide synthase regulates endothelial inflammation,” Journal of Leukocyte Biology, vol. 91, no. 6, pp. 947–956, 2012. View at Google Scholar
  32. S. Nakata, M. Tsutsui, H. Shimokawa et al., “Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-κB pathway,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 1, pp. 92–98, 2007. View at Publisher · View at Google Scholar · View at Scopus