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The Scientific World Journal
Volume 2013, Article ID 909746, 1 page

Cardiac Electrophysiology

1Department of Cardiology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
2Department of Cardiology, Xiehe Hospital of Huazhong University of Science and Technology, Wuhan 430022, China
3Department of Physiology, Loyola University Chicago, Maywood, IL 60153, USA

Received 21 July 2013; Accepted 21 July 2013

Copyright © 2013 Yanggan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Recently, significant achievements have been made in cardiac electrophysiology research, including Ca2+ regulatory pathways, membrane ion channel-related intracellular signaling, and electrical remodeling in cardiomyopathies. The rapid progress in the basic research has led to applications of numerous new methods and strategies to clinical diagnoses and treatments. The efficacy of antiarrhythmic pharmacotherapy remains a major challenge, but recent insights into complex mechanisms of electrical remodeling and new therapeutic strategies have raised the prospect of targeting arrhythmogenic substrates.

This special issue introduces recent progress in this area with special focus on atrial fibrillation, one of the most common arrhythmias in structural heart diseases. Papers published in this issue include basic research in ion channels, polymorphisms associated with lone atrial fibrillation, low-level autonomic stimulation on prevention of atrial fibrillation, new clinical methods for diagnosis and treatment of atrial fibrillation, and the pivotal role of cardiac imaging and electrocardiogram in assessing the effectiveness of cardiac resynchronization therapy. Due to volume limits, several important areas have not been included in this issue. However, we plan to discuss these topics in future issues.

Yanggan  Wang
Yimei  Du
Xun  Ai