Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma

Table 2

MMP-9 expression in oral cancer.

MMP-9 expression	Sample type	Lymph node metastasis	Outcome	MMP-9 activity	Method	Number of cases	References
High	Tissue	Yes	*	*	Immunohistochemistry	96	[70]
Yes	Tissue	Yes	*	*	Immunohistochemistry	61	[71]
High	Tissue	*	Shortened disease survival	High	Gelatin zymography,	44	[72]
Yes	Tissue	No	nc	*	Immunohistochemistry	23	[73]
High	Tissue	Yes	Poor	*	Immunohistochemistry	53	[74]
High	Tissue	No	*	High	Gelatin zymography, immunohistochemistry, western blot	57	[75]
High	Tissue	*	*	Low	Immunohistochemistry, gelatin zymography,	31	[76]
High	Plasma	No	*	*	ELISA	195	[77]
Yes	Tissue	No	nc	*	Immunohistochemistry	68	[78]
High	Tissue	*	Better survival	*	Immunohistochemistry	12	[79]
High	Tissue	Yes	Shortened disease survival	*	Immunohistochemistry	48	[80]

*not studied, nc: no correlation.