Review Article
MicroRNAs in Hepatocellular Carcinoma: Regulation, Function, and Clinical Implications
Table 3
Clinical relevance of deregulated microRNAs in HCC.
| miRNA | Expression in HCC | Clinical relevance |
| miR-122 [179] | Down | Poor prognosis | miR-124 [173] | Down | More aggressive and/or poor prognosis | miR-139 [107] | Down | Poor prognosis | miR-145 [110] | Down | Shorter disease-free survival | miR-199b [180] | Down | Poorer overall survival, and progression-free survival rates | miR-22 [181] | Down | Poor survival | miR-26 [182] | Down | Shorter overall survival | miR-29 [69] | Down | Worse disease-free survival | miR-99a [183] | Down | Shorter survival | let-7g [95] | Down | Poor survival | miR-10b [129] | Up | Poor prognosis | miR-125b [184] | Up | Good survival | miR-135a [131] | Up | Poor prognosis | miR-17-5p [185] | Up | Worse Edmondson-Steiner grade, vein invasion, shortened overall survival and disease-free survival | serum miR-17-5p [186] | Up | Poor prognosis | miR-155 [187] | Up | Poorer recurrence-free survival and overall survival | miR-182 [135] | Up | Intrahepatic metastasis and poor prognosis | C19MC miRNA [177] | Up | Increased risk of tumor recurrence and shorter overall survival time | miR-21 [188] | Up | Poor prognosis | miR-221 [188] | Up | Poor prognosis | miR-222 [178] | Up | Shorter disease-free survival | 20-miRNA signature [189] | Up/down | Metastases and recurrence | 19-miRNA signature [190] | Down | Poor survival |
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