The Scientific World Journal / 2013 / Article / Tab 5

Review Article

Efficacy of Memantine, Donepezil, or Their Association in Moderate-Severe Alzheimer’s Disease: A Review of Clinical Trials

Table 5

Clinical trials characteristics and results of the association of donepezil plus memantine in moderate-severe AD.

First author and no. in the list of references Severity Mean age yearsMean MMSE at baselineDuration of the study Test

Howard et al. 2012 [29]MMSE 5–13 52 weeks295MMSE
BADLS
NPI
PROXY

Doody et al. 2012 [30]MMSE 0–20Memantine: 73.6 (8.63) 
Placebo: 74.0 (8.48)
13.8 (4.63)24 weeks1436MMSE
CIBIC-plus
ACDS-ADL-sev
SIB

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