Effect of Polyunsaturated Fatty Acids on Homocysteine Metabolism through Regulating the Gene Expressions Involved in Methionine Metabolism

Figure 2

Homocysteine metabolism. Mthfr:methylenetetrahydrofolate reductase; Sahh:S-adenosylhomocysteine hydrolase; Bhmt:betaine-homocysteine methyltransferase; Cbs: cystathionine beta synthase; Mat1a: methionine adenosyltransferase I, alpha; Pemt: phosphatidylethanolamine N-methyltransferase; Cse: cystathionine gamma-lyase; Chka: choline kinase alpha; Tyms: thymidylate synthetase; Chdh: choline dehydrogenase; Gnmt: glycine N-methyltransferase; Mthfs: 5,10-methenyltetrahydrofolate synthetase; Mtr: 5-methyltetrahydrofolate-homocysteine methyltransferase; Cept1, choline/ethanolamine phosphotransferase 1; Mtrr: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Bad: betaine aldehyde dehydrogenase; Etnk1: ethanolamine kinase 1.