Sorafenib in Advanced Hepatocellular Carcinoma: A Nationwide Retrospective Study of Efficacy and Tolerability

Table 3

Adverse events during sorafenib therapy.

Adverse event*	All grades (%)	Grades 3-4 (%)
Fatigue	68	12
Anorexia	47	7
Diarrhoea	42	11
Rash	33	4
Nausea	32	3
Hand-foot syndrome	26	12
Hypertension	18	3
Vomiting	16	3
Thrombocytopenia	5	3
Bone marrow suppression	4	—
Metabolic/laboratory	4	1
Haemorrhage	4	—

∗Adverse events based on information in medical records and graded according to NCI-CTCAE v3.0.