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The Scientific World Journal
Volume 2013, Article ID 980419, 9 pages
http://dx.doi.org/10.1155/2013/980419
Review Article

Promising New Treatments for Psoriasis

1Centre LOEX de l'Université Laval, Génie Tissulaire et Régénération, LOEX-Centre de Recherche FRSQ du CHU, Aile-R, 1401 18e rue, Québec, QC, Canada G1J 1Z4
2Faculté de Pharmacie, Université Laval, Québec, QC, Canada G1V 0A6

Received 2 May 2013; Accepted 13 June 2013

Academic Editors: M. S. Chimenti and A. J. Stratigos

Copyright © 2013 Sarah Dubois Declercq and Roxane Pouliot. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Psoriasis is a chronic, proliferative, and inflammatory skin disease affecting 2-3% of the population and is characterized by red plaques with white scales. Psoriasis is a disease that can affect many aspects of professional and social life. Currently, several treatments are available to help control psoriasis such as methotrexate, ciclosporin, and oral retinoids. However, the available treatments are only able to relieve the symptoms and lives of individuals. The discovery of new immunological factors and a better understanding of psoriasis have turned to the use of immunological pathways and could develop new biological drugs against specific immunological elements that cause psoriasis. Biological drugs are less toxic to the body and more effective than traditional therapies. Thus, they should improve the quality of life of patients with psoriasis. This review describes new psoriasis treatments, which are on the market or currently in clinical trials that are being used to treat moderate-to-severe plaque psoriasis. In addition, this paper describes the characteristics and mechanisms in detail. In general, biological drugs are well tolerated and appear to be an effective alternative to conventional therapies. However, their effectiveness and long-term side effects need to be further researched.