The Mitigating Effect of Citrullus colocynthis (L.) Fruit Extract against Genotoxicity Induced by Cyclophosphamide in Mice Bone Marrow Cells

Table 1

Frequency of MnPCE and mitotic activity (% PCE) in bone marrow cells of mice treated with CCT fruits extract and/or CP.

Group	Treatment	% MnPCE^a	% PCE^a
1	Control	0.54±0.08	51.32±6.21
2	CP	6.14±0.36^b	32.48±4.15^b
3	CCT 10 mg/kg + CP	5.94±0.72^d	31.28±7.85^d
4	CCT 50 mg/kg + CP	3.62±0.81^f	40.62±5.14^f
5	CCT 100 mg/kg + CP	1.04±0.27^c,e	48.89±6.78^c,e
6	CCT 200 mg/kg + CP	0.92±0.06^c,e	50.32±8.01^c,e
7	CCT 200 mg/kg	0.47±0.14^e	51.79±5.46^e

CCT: Citrullus colocynthis; CP: cyclophosphamide; MnPCE: micronucleated polychromatic erythrocyte.
^aValues are the mean ± standard deviation for each group of 5 mice. ^b𝑃<0.0001 compared to the control; ^c𝑃<0.0001 compared with the CP treated group; ^f𝑃<0.001 compared with the CP treated group. ^dNo significant difference compared to the CP group. ^eNo significant difference compared to the control group.
The data were analyzed with one-way ANOVA and Tukey’s HSD test.