Expression Profiling Using a cDNA Array and Immunohistochemistry for the Extracellular Matrix Genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in Colorectal Carcinoma Progression and Dissemination

Table 1

Characteristics of the 114 patients included in the study.

Variables	𝑛	%
Age
<60 years; >60 years	56; 58	49.1; 50.9
Gender
Female; Male	51; 63	44.7; 55.3
Primary tumor site
Right colon; Left colon; Rectum	41; 41; 32	36.0; 36.0; 28.0
Synchronous tumor
No; Yes	112; 2	98.2; 1.8
Histological classification
Adenocarcinoma SOE; Adenocarcinoma mucinous; Adenocarcinoma villous	81; 18; 15	71.0; 15.8; 13.2
Grading: cell differentiation
Well differentiated; Moderate; Poor; Undifferentiated	9; 91; 14; 0	7.9; 79.8; 12.3; 0
Venous invasion
Absent; Present	93; 21	81.6; 18.4
Lymphatic vessels invasion
Absent; Present	91; 23	79.8; 20.2
Perineural invasion
Absent; Present	106; 8	93.0; 7.0
Peritumoural lymphocyte infiltration
Absent; Present	21; 93	18.4; 81.6
Resection margin status
Positive; Negative	0; 114	0; 100.0
Lymph nodes dissected
Median; Range	17*	3–67
Tumor stage: TNM
T1; T2; T3; T4	5; 27; 71; 11	4.4; 23.7; 62.3; 9.6
Nodal stage
N0; N1; N2	67; 25; 22	58.8; 21.9; 19.3
Distant metastasis
Absent; Present	98; 16	85.9; 14.1
Site of distant metastasis
Absent; Liver; Peritoneum; Lungs; Ovary	98; 9; 3; 2; 2	85.9; 7.9; 2.6; 1.8; 1.8
Clinical stage
I; II; III; IV	25; 39; 34; 16	21.9; 34.2; 29.8; 14.0

∗28 patients had <12 lymph nodes dissected or analyzed.