The Scientific World Journal

Research Article

Expression Profiling Using a cDNA Array and Immunohistochemistry for the Extracellular Matrix Genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in Colorectal Carcinoma Progression and Dissemination

Table 3

Distribution of the expression levels PER IHC of proteins corresponding to ITGB-5, ITGA-3, MMP-2, MMP-9, and FN-1 ECM genes and EGFR, VEGF, KI-67, P53, and Bcl-2 molecules as per the degree of cell differentiation of CRC ().


Grading tumor cell differentiation	EGFR		Total	value
Grading tumor cell differentiation	High	Low	Total	value

I + II				0.159
	63	37	100
%	63.0%	37.0%	100.0%
III
	6	8	14
%	42.9%	57.1%	100.0%
Total
	69	45	114
%	60.5%	39.5%	100.0%

Grading tumor cell differentiation	VEGF		Total	P value
Grading tumor cell differentiation	High	Low	Total	P value

I + II				0.778
	49	51	100
%	49.0%	51.0%	100.0%
III
	6	8	14
%	42.9%	57.1%	100.0%
Total
	55	59	114
%	48.2%	51.8%	100.0%

Grading tumor cell differentiation	KI-67		Total	P value
Grading tumor cell differentiation	High	Low	Total	P value

I + II				0.093
	46	54	100
%	46.0%	54.0%	100.0%
III
	3	11	14
%	21.4%	78.6%	100.0%
Total
	49	65	114
%	43.0%	57.0%	100.0%

Grading tumor cell differentiation	P53		Total	P value
Grading tumor cell differentiation	High	Low	Total	P value

I + II				0.778
	41	59	100
%	41.0%	59.0%	100.0%
III
	5	9	14
%	35.7%	64.3%	100.0%
Total
	46	68	114
%	40.4%	59.6%	100.0%

Grading tumor cell differentiation	Bcl-2		Total	P value
Grading tumor cell differentiation	High	Low	Total	P value

I + II				1.000
	50	50	100
%	50.0%	50.0%	100.0%
III
	7	7	14
%	50.0%	50.0%	100.0%

Grading tumor cell differentiation	ITGB-5		Total	P value
Grading tumor cell differentiation	High	Low	Total	P value

I + II				0.394
	57	43	100
%	57.0%	43.0%	100.0%
III
	6	8	14
%	42.9%	57.1%	100.0%
Total
	63	51	114
%	55.3%	44.7%	100.0%

Grading tumor cell differentiation	ITGA-3		Total	P value
Grading tumor cell differentiation	High	Low	Total	P value

I + II				0.397
	50	50	100
%	50.0%	50.0%	100.0%
III
	5	9	14
%	35.7%	64.3%	100.0%
Total
	55	59	114
%	48.2%	51.8%	100.0%

Grading tumor cell differentiation	MMP-2		Total	P value
Grading tumor cell differentiation	High	Low	Total	P value

I + II				0.568
	48	52	100
%	48.0%	52.0%	100.0%
III
	5	9	14
%	35.7%	64.3%	100.0%
Total
	53	61	114
%	46.5%	53.5%	100.0%

Grading tumor cell differentiation	MMP-9		Total	P value
Grading tumor cell differentiation	High	Low	Total	P value

I + II				0.572
	53	47	100
%	53.0%	47.0%	100.0%
III
	6	8	14
%	42.9%	57.1%	100.0%
Total
	59	55	114
%	51.8%	48.2%	100.0%

Grading tumor cell differentiation	FN-1		Total	P value
Grading tumor cell differentiation	High	Low	Total	P value

I + II				0.225
	73	27	100
%	73.0%	27.0%	100.0%
III
	8	6	14
%	57.1%	42.9%	100.0%
Total
	81	33	114
%	71.1%	28.9%	100.0%