The Scientific World Journal

Research Article

Expression Profiling Using a cDNA Array and Immunohistochemistry for the Extracellular Matrix Genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in Colorectal Carcinoma Progression and Dissemination

Table 4

The distribution of expression levels per IHC of proteins corresponding to ITGB-5, ITGA-3, MMP-2, MMP-9, and FN-1 ECM genes and EGFR, VEGF, KI-67, P53, and Bcl-2 molecules as per the degree of TNM staging of CRC ().


TNM tumor stage	EGFR		Total	value
TNM tumor stage	High	Low	Total	value

I + II				0.000
	64	0	64
%	100.0%	0.0%	100.0%
III + IV
	5	45	50
%	10.0%	90.0%	100.0%
Total
	69	45	114
%	60.5%	39.5%	100.0%

TNM tumor stage	VEGF		Total	P value
TNM tumor stage	High	Low	Total	P value

I + II				0.186
	27	37	64
%	42.2%	57.8%	100.0%
III + IV
	28	22	50
%	56.0%	44.0%	100.0%
Total
	55	59	114
%	48.2%	51.8%	100.0%

TNM tumor stage	KI-67		Total	P value
TNM tumor stage	High	Low	Total	P value

I + II				0.000
	38	26	64
%	59.4%	40.6%	100.0%
III + IV
	11	39	50
%	22.0%	78.0%	100.0%
Total
	49	65	114
%	43.0%	57.0%	100.0%

Estadiamento	P53		Total	P value
Estadiamento	High	Low	Total	P value

I + II				0.000
	35	29	64
%	54.7%	45.3%	100.0%
III + IV
	11	39	50
%	22.0%	78.0%	100.0%
Total
	46	68	114
%	40.4%	59.6%	100.0%

TNM tumor stage	Bcl-2		Total	P value
TNM tumor stage	High	Low	Total	P value

I + II				0.345
	29	35	64
%	45.3%	54.7%	100.0%
III + IV
	28	22	50
%	56.0%	44.0%	100.0%
Total
	57	57	114
%	50.0%	50.0%	100.0%

TNM tumor stage	ITGB-5		Total	P value
TNM tumor stage	High	Low	Total	P value

I + II				0.000
	49	15	64
%	76.6%	23.4%	100.0%
III + IV
	14	36	50
%	28.0%	72.0%	100.0%
Total
	63	51	114
%	55.3%	44.7%	100.0%

TNM tumor stage	ITGA-3		Total	P value
TNM tumor stage	High	Low	Total	P value

I + II				0.000
	53	11	64
%	82.8%	17.2%	100.0%
III + IV
	2	48	50
%	4.0%	96.0%	100.0%
Total
	55	59	114
%	48.2%	51.8%	100.0%

TNM tumor stage	MMP-2		Total	P value
TNM tumor stage	High	Low	Total	P value

I + II				0.572
	28	36	64
%	43.8%	56.3%	100.0%
III + IV
	25	25	50
%	50.0%	50.0%	100.0%
Total
	53	61	114
%	46.5%	53.5%	100.0%

TNM tumor stage	MMP-9		Total	P value
TNM tumor stage	High	Low	Total	P value

I + II				0.000
	56	8	64
%	87.5%	12.5%	100.0%
III + IV
	3	47	50
%	6.0%	94.0%	100.0%
Total
	59	55	114
%	51.8%	48.2%	100.0%

TNM tumor stage	FN-1		Total	P value
TNM tumor stage	high	low	Total	P value

I + II				0.677
	44	20	64
%	68.8%	31.3%	100.0%
III + IV
	37	13	50
%	74.0%	26.0%	100.0%
Total
	81	33	114
%	71.1%	28.9%	100.0%