The Scientific World Journal

Research Article

Expression Profiling Using a cDNA Array and Immunohistochemistry for the Extracellular Matrix Genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in Colorectal Carcinoma Progression and Dissemination

Table 5

The distribution of expression levels per IHC of proteins corresponding to ITGB-5, ITGA-3, MMP-2, MMP-9, and FN-1 ECM genes and EGFR, VEGF, KI-67, P53, and Bcl-2 molecules as per the peritumoral lymphocyte infiltrate in CRC ().


Peritumoral lymphocyte infiltrate	EGFR		Total	value
Peritumoral lymphocyte infiltrate	High	Low	Total	value

Absence
	13	8	21	1.000
%	61.9%	38.1%	100.0%
Presence
	56	37	93
%	60.2%	39.8%	100.0%
Total
	69	45	114
%	60.5%	39.5%	100.0%

Peritumoral lymphocyte infiltrate	VEGF		Total	P value
Peritumoral lymphocyte infiltrate	High	Low	Total	P value

Absence				0.635
	9	12	21
%	42.9%	57.1%	100.0%
Presence
	46	47	93
%	49.5%	50.5%	100.0%
Total
	55	59	114
%	48.2%	51.8%	100.0%

Peritumoral lymphocyte infiltrate	KI-67		Total	P value
Peritumoral lymphocyte infiltrate	High	Low	Total	P value

Absence
	11	10	21	0.343
%	52.4%	47.6%	100.0%
Presence
	38	55	93
%	40.9%	59.1%	100.0%
Total
	49	65	114
%	43.0%	57.0%	100.0%

Peritumoral lymphocyte infiltrate	P53		Total	P value
Peritumoral lymphocyte infiltrate	High	Low	Total	P value

Absence				1.000
	8	13	21
%	38.1%	61.9%	100.0%
Presence
	38	55	93
%	40.9%	59.1%	100.0%
Total
	46	68	114
%	40.4%	59.6%	100.0%

Peritumoral lymphocyte infiltrate	Bcl-2		Total	P value
Peritumoral lymphocyte infiltrate	High	Low	Total	P value

Absence				0.629
	9	12	21
%	42.9%	57.1%	100.0%
Presence
	48	45	93
%	51.6%	48.4%	100.0%
Total
	57	57	114
%	50.0%	50.0%	100.0%

Peritumoral lymphocyte infiltrate	ITGB-5		Total	P value
Peritumoral lymphocyte infiltrate	High	Low	Total	P value

Absence				1.000
	12	9	21
%	57.1%	42.9%	100.0%
Presence
	51	42	93
%	54.8%	45.2%	100.0%
Total
	63	51	114
%	55.3%	44.7%	100.0%

Peritumoral lymphocyte infiltrate	ITGA-3		Total	P value
Peritumoral lymphocyte infiltrate	High	Low	Total	P value

Absence				0.227
	13	8	21
%	61.9%	38.1%	100.0%
Presence
	42	51	93
%	45.2%	54.8%	100.0%
Total
	55	59	114
%	48.2%	51.8%	100.0%

Peritumoral lymphocyte infiltrate	MMP-2		Total	P value
Peritumoral lymphocyte infiltrate	High	Low	Total	P value

Absence				1.000
	10	11	21
%	47.6%	52.4%	100.0%
Presence
	43	50	93
%	46.2%	53.8%	100.0%
Total
	53	61	114
%	46.5%	53.5%	100.0%

Peritumoral lymphocyte infiltrate	MMP-9		Total	P value
Peritumoral lymphocyte infiltrate	High	Low	Total	P value

Absence				1.000
	11	10	21
%	52.4%	47.6%	100.0%
Presence
	48	45	93
%	51.6%	48.4%	100.0%
Total
	59	55	114
%	51.8%	48.2%	100.0%

Peritumoral lymphocyte infiltrate	FN-1		Total	P value
Peritumoral lymphocyte infiltrate	High	Low	Total	P value

Absence				0.180
	12	9	21
%	57.1%	42.9%	100.0%
Presence
	69	24	93
%	74.2%	25.8%	100.0%
Total
	81	33	114
%	71.1%	28.9%	100.0%