The Scientific World Journal

Research Article

Expression Profiling Using a cDNA Array and Immunohistochemistry for the Extracellular Matrix Genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in Colorectal Carcinoma Progression and Dissemination

Table 6

The distribution of expression levels per IHC of proteins corresponding to ITGB-5, ITGA-3, MMP-2, and MMP9 ECM genes and FN-1 and EGFR, VEGF, KI-67, P53, and Bcl-2 molecules as per the presence of venous invasion in CRC ().


Venous invasion	EGFR		Total	value
Venous invasion	High	Low	Total	value

Absence				0.000
	65	28	93
%	69.9%	30.1%	100.0%
Presence
	4	17	21
%	19.0%	81.0%	100.0%
Total
	69	45	114
%	60.5%	39.5%	100.0%

Venous invasion	VEGF		Total	P value
Venous invasion	High	Low	Total	P value

Absence				0.810
	44	49	93
%	47.3%	52.7%	100.0%
Presence
	11	10	21
%	52.4%	47.6%	100.0%
Total
	55	59	114
%	48.2%	51.8%	100.0%

Venous invasion	KI-67		Total	P value
Venous invasion	High	Low	Total	P value

Absence				0.055
	44	49	93
%	47.3%	52.7%	100.0%
Presence
	5	16	21
%	23.8%	76.2%	100.0%
Total
	49	65	114
%	43.0%	57.0%	100.0%

Venous invasion	P53		Total	P value
Venous invasion	High	Low	Total	P value

Absence				0.029
	42	51	93
%	45.2%	54.8%	100.0%
Presence
	4	17	21
%	19.0%	81.0%	100.0%
Total
	46	68	114
%	40.4%	59.6%	100.0%

Venous invasion	Bcl-2		Total	P value
Venous invasion	High	Low	Total	P value

Absence				1.000
	46	47	93
%	49.5%	50.5%	100.0%
Presence
	11	10	21
%	52.4%	47.6%	100.0%
Total
	57	57	114
%	50.0%	50.0%	100.0%

Venous invasion	ITGB-5		Total	P value
Venous invasion	High	Low	Total	P value

Absence				0.231
	54	39	93
%	58.1%	41.9%	100.0%
Presence
	9	12	21
%	42.9%	57.1%	100.0%
Total
	63	51	114
%	55.3%	44.7%	100.0%

Venous invasion	ITGA-3		Total	P value
Venous invasion	High	Low	Total	P value

Absence				0.000
	52	41	93
%	55.9%	44.1%	100.0%
Presence
	3	18	21
%	14.3%	85.7%	100.0%
Total
	55	59	114
%	48.2%	51.8%	100.0%

Venous invasion	MMP-2		Total	P value
Venous invasion	High	Low	Total	P value

Absence				0.631
	42	51	93
%	45.2%	54.8%	100.0%
Presence
	11	10	21
%	52.4%	47.6%	100.0%
Total
	53	61	114
%	46.5%	53.5%	100.0%

Venous invasion	MMP-9		Total	P value
Venous invasion	High	Low	Total	P value

Absence				0.001
	55	38	93
%	59.1%	40.9%	100.0%
Presence
	4	17	21
%	19.0%	81.0%	100.0%
Total
	59	55	114
%	51.8%	48.2%	100.0%

Venous invasion	FN-1		Total	P value
Venous invasion	High	Low	Total	P value

Absence				0.006
	61	32	93
%	65.6%	34.4%	100.0%
Presence
	20	1	21
%	95.2%	4.8%	100.0%
Total
	81	33	114
%	71.1%	28.9%	100.0%