The Scientific World Journal

Research Article

Expression Profiling Using a cDNA Array and Immunohistochemistry for the Extracellular Matrix Genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in Colorectal Carcinoma Progression and Dissemination

Table 7

The distribution of expression levels per IHC of proteins corresponding to ITGB-5, ITGA-3, MMP-2, MMP-9, and FN-1 ECM genes and EGFR, VEGF, Ki-67, P53, and Bcl-2 molecules as per the presence of perineural invasion in CRC ().


Perineural invasion	EGFR		Total	value
Perineural invasion	High	Low	Total	value

Absence				0.260
	66	40	106
%	62.3%	37.7%	100.0%
Presence
	3	5	8
%	37.5%	62.5%	100.0%
Total
	69	45	114
%	60.5%	39.5%	100.0%

Perineural invasion	VEGF		Total	P value
Perineural invasion	High	Low	Total	P value

Absence				0.027
	48	58	106
%	45.3%	54.7%	100.0%
Presence
	7	1	8
%	87.5%	12.5%	100.0%
Total
	55	59	114
%	48.2%	51.8%	100.0%

Perineural invasion	KI-67		Total	P value
Perineural invasion	High	Low	Total	P value

Absence				0.462
	47	59	106
%	44.3%	55.7%	100.0%
Presence
	2	6	8
%	25.0%	75.0%	100.0%
Total
	49	65	114
%	43.0%	57.0%	100.0%

Perineural invasion	P53		Total	P value
Perineural invasion	High	Low	Total	P value

Absence				0.470
	44	62	106
%	41.5%	58.5%	100.0%
Presence
	2	6	8
%	25.0%	75.0%	100.0%
Total
	46	68	114
%	40.4%	59.6%	100.0%

Perineural invasion	Bcl-2		Total	P value
Perineural invasion	High	Low	Total	P value

Absence				0.716
	52	54	106
%	49.1%	50.9%	100.0%
Presence
	5	3	8
%	62.5%	37.5%	100.0%
Total
	57	57	114
%	50.0%	50.0%	100.0%

Perineural invasion	ITGB-5		Total	P value
Perineural invasion	High	Low	Total	P value

Absence				0.463
	60	46	106
%	56.6%	43.4%	100.0%
Presence
	3	5	8
%	37.5%	62.5%	100.0%
Total
	63	51	114
%	55.3%	44.7%	100.0%

Perineural invasion	ITGA-3		Total	P value
Perineural invasion	High	Low	Total	P value

Absence				0.717
	52	54	106
%	49.1%	50.9%	100.0%
Presence
	3	5	8
%	37.5%	62.5%	100.0%
Total
	55	59	114
%	48.2%	51.8%	100.0%

Perineural invasion	MMP-2		Total	P value
Perineural invasion	High	Low	Total	P value

Absence				0.999
	49	57	106
%	46.2%	53.8%	100.0%
Presence
	4	4	8
%	50.0%	50.0%	100.0%
Total
	53	61	114
%	46.5%	53.5%	100.0%

Perineural invasion	MMP-9		Total	P value
Perineural invasion	High	Low	Total	P value

Absence				0.479
	56	50	106
%	52.8%	47.2%	100.0%
Presence
	3	5	8
%	37.5%	62.5%	100.0%
Total
	59	55	114
%	51.8%	48.2%	100.0%

Perineural invasion	FN-1		Total	P value
Perineural invasion	High	Low	Total	P value

Absence				0.102
	73	33	106
%	68.9%	31.1%	100.0%
Presence
	8	0	8
%	100.0%	0.0%	100.0%
Total
	81	33	114
%	71.1%	28.9%	100.0%