Expression Profiling Using a cDNA Array and Immunohistochemistry for the Extracellular Matrix Genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in Colorectal Carcinoma Progression and Dissemination

Table 8

The distribution of expression levels per IHC of proteins corresponding to ITGB-5, ITGA-3, MMP-2, MMP-9, and FN-1 ECM genes and EGFR, VEGF, KI-67, P53, and Bcl-2 molecules as per the villous and tubular types of CRC (𝑛=114).

Tumor histologic type: tubular × villous	EGFR		Total	𝑃 value
	High	Low
Tubular				0.579
𝑁	52	29	81
%	64.2%	35.8%	100.0%
Villous
𝑁	9	7	16
%	56.3%	43.8%	100.0%
Total
𝑁	61	36	97
%	62.9%	37.1%	100.0%
Tumor histologic type: tubular × villous	VEGF		Total	P value
	High	Low
Tubular				1.000
𝑁	41	40	81
%	50.6%	49.4%	100.0%
Villous
𝑁	8	8	16
%	50.0%	50.0%	100.0%
Total
𝑁	49	48	97
%	50.5%	49.5%	100.0%
Tumor histologic type: tubular × villous	KI-67		Total	P value
	High	Low
Tubular				0.783
𝑁	36	45	81
%	44.4%	55.6%	100.0%
Villous
𝑁	6	10	16
%	37.5%	62.5%	100.0%
Total
𝑁	42	55	97
%	43.3%	56.7%	100.0%
Tumor histologic type: tubular × villous	P53		Total	P value
	High	Low
Tubular				1.000
𝑁	32	49	81
%	39.5%	60.5%	100.0%
Villous
𝑁	6	10	16
%	37.5%	62.5%	100.0%
Total
𝑁	38	59	97
%	39.2%	60.8%	100.0%
Tumor histologic type: tubular × villous	Bcl-2		Total	P value
	High	Low
Tubular				0.277
𝑁	37	44	81
%	45.7%	54.3%	100.0%
Villous
𝑁	10	6	16
%	62.5%	37.5%	100.0%
Total
𝑁	47	50	97
%	48.5%	51.5%	100.0%
Tumor histologic type: tubular × villous	ITGB-5		Total	P value
	High	Low
Tubular				1.000
𝑁	44	37	81
%	54.3%	45.7%	100.0%
Villous
𝑁	9	7	16
%	56.3%	43.8%	100.0%
Total
𝑁	53	44	97
%	54.6%	45.4%	100.0%
Tumor histologic type: tubular × villous	ITGA-3		Total	P value
	High	Low
Tubular				1.000
𝑁	40	41	81
%	49.4%	50.6%	100.0%
Villous
𝑁	8	8	16
%	50.0%	50.0%	100.0%
Total
𝑁	48	49	97
%	49.5%	50.5%	100.0%
Tumor histologic type: tubular × villous	MMP-2		Total	P value
	High	Low
Tubular				0.585
𝑁	44	37	81
%	54.3%	45.7%	100.0%
Villous
𝑁	7	9	16
%	43.8%	56.3%	100.0%
Total
𝑁	51	46	97
%	52.6%	47.4%	100.0%
Tumor histologic type: tubular × villous	MMP-9		Total	P value
	High	Low
Tubular				0.000
𝑁	49	32	81
%	60.5%	39.5%	100.0%
Villous
𝑁	1	15	16
%	6.3%	93.8%	100.0%
Total
𝑁	50	47	97
%	51.5%	48.5%	100.0%
Tumor histologic type: tubular × villous	FN-1		Total	P value
	High	Low
Tubular				1.000
𝑁	57	24	81
%	70.4%	29.6%	100.0%
Villous
𝑁	11	5	16
%	68.8%	31.3%	100.0%
Total
𝑁	68	29	97
%	70.1%	29.9%	100.0%