Expression Profiling Using a cDNA Array and Immunohistochemistry for the Extracellular Matrix Genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in Colorectal Carcinoma Progression and Dissemination

Table 9

The distribution of expression levels per IHC of proteins corresponding to ITGB-5, ITGA-3, MMP-2, MMP-9, and FN-1 ECM genes and EGFR, VEGF, KI-67, P53, and Bcl-2 molecules as per mucinous and tubular tumor types of CRC (𝑛=114).

Tumor histologic type: mucinous × tubular	EGFR		Total	𝑃 value
	High	Low
Mucinous				0.273
𝑁	8	9	17
%	47.1%	52.9%	100.0%
Tubular
𝑁	52	29	81
%	64.2%	35.8%	100.0%
Total
𝑁	60	38	98
%	61.2%	38.8%	100.0%
Tumor histologic type: mucinous × tubular	VEGF		Total	P value
	High	Low
Mucinous				0.294
𝑁	6	11	17
%	35.3%	64.7%	100.0%
Tubular
𝑁	41	40	81
%	50.6%	49.4%	100.0%
Total
𝑁	47	51	98
%	48.0%	52.0%	100.0%
Tumor histologic type: mucinous × tubular	KI-67		Total	P value
	High	Low
Mucinous				1.000
𝑁	7	10	17
%	41.2%	58.8%	100.0%
Tubular
𝑁	36	45	81
%	44.4%	55.6%	100.0%
Total
𝑁	43	55	98
%	43.9%	56.1%	100.0%
Tumor histologic type: mucinous × tubular	P53		Total	P value
	High	Low
Mucinous				0.596
𝑁	8	9	17
%	47.1%	52.9%	100.0%
Tubular
𝑁	32	49	81
%	39.5%	60.5%	100.0%
Total
𝑁	40	58	98
%	40.8%	59.2%	100.0%
Tumor histologic type: mucinous × tubular	Bcl-2		Total	P value
	High	Low
Mucinous				0.425
𝑁	10	7	17
%	58.8%	41.2%	100.0%
Tubular
𝑁	37	44	81
%	45.7%	54.3%	100.0%
Total
𝑁	47	51	98
%	48.0%	52.0%	100.0%
Tumor histologic type: mucinous × tubular	ITGB-5		Total	P value
	High	Low
Mucinous				0.793
𝑁	10	7	17
%	58.8%	41.2%	100.0%
Tubular
𝑁	44	37	81
%	54.3%	45.7%	100.0%
Total
𝑁	54	44	98
%	55.1%	44.9%	100.0%
Tumor histologic type: mucinous × tubular	ITGA-3		Total	P value
	High	Low
Mucinous				0.600
𝑁	7	10	17
%	41.2%	58.8%	100.0%
Tubular
𝑁	40	41	81
%	49.4%	50.6%	100.0%
Total
𝑁	47	51	98
%	48.0%	52.0%	100.0%
Tumor histologic type: mucinous × tubular	MMP-2		Total	P value
	High	Low
Mucinous				0.001
𝑁	2	15	17
%	11.8%	88.2%	100.0%
Tubular
𝑁	44	37	81
%	54.3%	45.7%	100.0%
Total
𝑁	46	52	98
%	46.9%	53.1%	100.0%
Tumor histologic type: mucinous × tubular	MMP-9		Total	P value
	High	Low
Mucinous				0.596
𝑁	9	8	17
%	52.9%	47.1%	100.0%
Tubular
𝑁	49	32	81
%	60.5%	39.5%	100.0%
Total
𝑁	58	40	98
%	59.2%	40.8%	100.0%
Tumor histologic type: mucinous × tubular	FN-1		Total	P value
	High	Low
Mucinous				0.771
𝑁	13	4	17
%	76.5%	23.5%	100.0%
Tubular
𝑁	57	24	81
%	70.4%	29.6%	100.0%
Total
𝑁	70	28	98
%	71.4%	28.6%	100.0%