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The Scientific World Journal
Volume 2014 (2014), Article ID 102736, 13 pages
http://dx.doi.org/10.1155/2014/102736
Review Article

Can Vascular Endothelial Growth Factor and Microvessel Density Be Used as Prognostic Biomarkers for Colorectal Cancer? A Systematic Review and Meta-Analysis

Department of Epidemiology, Public Health College, Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, Heilongjiang 150081, China

Received 11 November 2013; Accepted 29 January 2014; Published 27 March 2014

Academic Editors: E. Z. Dajani and C. Tosetti

Copyright © 2014 Yibaina Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Online Resource 1 showed the quality assessment questionnaire, which was used to weight the quality and applicability of the included studies from research design, laboratory methodology and analysis of the results.

Online Resources 2 summarized the main characteristics of the VEGF related studies, and the characteristics included detail information of the study population, median months of follow-up, HR value, adjusted variable in Cox analysis and quality scoring of each article.

Online Resources 3 summarized the main characteristics of the MVD related studies, and the characteristics included detail information of the study population, median months of follow-up, HR value, adjusted variable in Cox analysis and quality scoring of each article.

Online Resources 4 described the determination method of cut-off criteria and the specific cut-off value for VEGF/MVD in each study. And the cut-off value was used to assess the expression level of VEGF or MVD.

  1. Supplementary Materials