Can Vascular Endothelial Growth Factor and Microvessel Density Be Used as Prognostic Biomarkers for Colorectal Cancer? A Systematic Review and Meta-Analysis

Table 2

Pooled ORs for the association between VEGF expression and clinical and pathology features.

	Number of studies	Pooled OR; (95% CI)	𝑃 value
Gender^1	13	1.08 (0.84–1.38)	0.55
Distant metastasis^2	8	4.22 (2.93–6.06)	<0.01
Lymph node metastasis^2	15	2.51 (1.51–4.15)	<0.01
Lymph metastasis^2	7	1.57 (0.97–2.54)	0.06
Vascular metastasis^2	9	2.38 (1.49–3.79)	<0.01
TNM^3	13	1.65 (0.92–2.96)	0.09

OR: odds ratio; VEGF: vascular endothelial growth factor.
¹Male versus female; ²metastasis of positive versus metastasis of negative; ³I and II versus III and IV.