Can Vascular Endothelial Growth Factor and Microvessel Density Be Used as Prognostic Biomarkers for Colorectal Cancer? A Systematic Review and Meta-Analysis
Table 3
Pooled ORs for the association between MVD expression and clinical and pathology features both in qualitative and quantitative analyses.
Qualitative analyses
Quantitative analyses
Number of studies
Pooled OR (95% CI)
value
Number of studies
MD (95% CI)
value
SMD (95% CI)
value
Gender1
8
0.94 (0.71–1.24)
0.66
11
−4.43 (−18.82–9.96)
0.55
−0.76 (−1.36–0.15)
0.01
Grade2
11
1.47 (0.86–2.49)
0.15
—
—
—
—
—
Distant metastasis3
—
—
—
8
13.14 (−1.70–27.98)
0.08
1.43 (0.27–2.59)
0.02
Lymph node metastasis3
8
1.84 (1.19–2.85)
<0.01
10
7.97 (3.64–12.31)
<0.01
0.45 (0.22–0.69)
<0.01
Lymph metastasis3
5
1.76 (0.97–3.20)
0.06
6
7.15 (3.86–10.44)
<0.01
0.46 (0.28–0.64)
<0.01
Vascular metastasis3
7
1.43 (1.06–1.92)
0.02
8
13.99 (5.15–22.83)
<0.01
0.60 (0.26–0.95)
<0.01
MD: mean difference; MVD: microvessel density; OR: odds ratio; SMD: standardized mean difference.
1Male versus female, 2well and moderate versus poor and mucinous, and 3metastasis of positive versus metastasis of negative.
