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The Scientific World Journal
Volume 2014, Article ID 103462, 15 pages
http://dx.doi.org/10.1155/2014/103462
Research Article

Direct Synthesis and Morphological Characterization of Gold-Dendrimer Nanocomposites Prepared Using PAMAM Succinamic Acid Dendrimers: Preliminary Study of the Calcification Potential

1METAV Research and Development, 31 C.A. Rosetti, Sector 2, 020015 Bucharest, Romania
2Advanced Polymer Materials Group, University Politehnica of Bucharest, 149 Calea Victoriei, Sector 1, 010072 Bucharest, Romania
3Polymer Chemistry and Biomaterials Group, Ghent University, Krijgslaan 281 (S4), 9000 Ghent, Belgium

Received 30 August 2013; Accepted 12 November 2013; Published 28 January 2014

Academic Editors: L. Visai and C.-H. Yao

Copyright © 2014 E. Vasile et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gold-dendrimer nanocomposites were obtained for the first time by a simple colloidal approach based on the use of polyamidoamine dendrimers with succinamic acid terminal groups and dodecanediamine core. Spherical and highly crystalline nanoparticles with dimensions between 3 nm and 60 nm, and size-polydispersity depending on the synthesis conditions, have been generated. The influence of the stoichiometric ratio and the structural and architectural features of the dendrimers on the properties of the nanocomposites has been described. The self-assembling behaviour of these materials produces gold-dendrimer nanostructured porous networks with variable density, porosity, and composition. The investigations of the reaction systems, by TEM, at two postsynthesis moments, allowed to preliminary establish the control over the properties of the nanocomposite products. Furthermore, this study allowed better understanding of the mechanism of nanocomposite generation. Impressively, in the early stages of the synthesis, the organization of gold inside the dendrimer molecules has been evidenced by micrographs. Growth and ripening mechanisms further lead to nanoparticles with typical characteristics. The potential of such nanocomposite particles to induce calcification when coating a polymer substrate was also investigated.