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The Scientific World Journal
Volume 2014, Article ID 121679, 8 pages
Research Article

C-Reactive Protein and Cognition Are Unrelated to Leukoaraiosis

1Division of Geriatric Neurology, Service of Neurology, “Hospital de Clinicas de Porto Alegre” (HCPA), Ramiro Barcelos Street 2.350, 90035-903 Porto Alegre, RS, Brazil
2Division of Gerontological Nursing, Faculty of Nursing, Federal University of Rio Grande do Sul (UFRGS), São Manoel Street 963, 90620-110 Porto Alegre, RS, Brazil
3Department of Internal Medicine, Faculty of Medicine, Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street 2.040, 90035-903 Porto Alegre, RS, Brazil

Received 23 August 2013; Accepted 21 October 2013; Published 22 January 2014

Academic Editors: P. Trombley and Y. Yoshiyama

Copyright © 2014 Liara Rizzi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Elevated serum levels of C-reactive protein (CRP) have been associated with leukoaraiosis in elderly brain. However, several studies indicate that leukoaraiosis is associated with an increased risk of cognitive impairment. It is unknown how the effect of CRP on cognition is mediated by leukoaraiosis. The purpose of this study is to assess the relationship between serum levels of CRP, the presence of leukoaraiosis, and cognitive impairment in a population of coronary patients over 50 years old. CRP levels explained 7.18% (: 0.002) of the variance of the MMSE. The adjustment for the presence of leukoaraiosis little changed this variance (5.98%, : 0.005), indicating that only a small portion of the CRP influence on cognition was mediated via leukoaraiosis. Patients with CRP levels ≥5.0 had 2.9 (95% CI: 1.26–6.44) times more chance to present cognitive impairment (: 0.012). We found that elevated serum levels of CRP were associated with increased risk of cognitive impairment in elderly and it was not mediated by presence of leukoaraiosis.