Adaptation of Mycoplasmas to Antimicrobial Agents: <i>Acholeplasma laidlawii</i> Extracellular Vesicles Mediate the Export of Ciprofloxacin and a Mutant Gene Related to the Antibiotic Target

<table>Relationships between typical cells and extracellular vesicles (EVs) (a, c, e) and transmission electron microscopy images (b, d, f) (extracellular vesicles (indicated by arrows)) of <i>Acholeplasma laidlawii</i> PG8 without ciprofloxacin (a, b), in the presence of antibiotic **(c, d) and <i>A. laidlawii</i> PG8R (e, f) (according to transmission electron microscopy). Each point corresponds to the linear size of individual cells or EVs. <svg height="13.95" id="M2" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>. **Treatment with ciprofloxacin for 80 min.</table>

The Scientific World Journal

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Figure 2

Figure 2: Adaptation of Mycoplasmas to Antimicrobial Agents: <i>Acholeplasma laidlawii</i> Extracellular Vesicles Mediate the Export of Ciprofloxacin and a Mutant Gene Related to the Antibiotic Target 

Figure 2 | Adaptation of Mycoplasmas to Antimicrobial Agents: Acholeplasma laidlawii Extracellular Vesicles Mediate the Export of Ciprofloxacin and a Mutant Gene Related to the Antibiotic Target 