Today Prospects for Tissue Engineering Therapeutic Approach in Dentistry

Table 1

In vivo studies dealing with dental stem cells applications in tissue engineering procedures.

Type of cell	Origin	Year	Reference	Scaffold	GFs	Animal model	Type of differentiation
DFSC	Bovine	2002	Handa et al. [52]	HA ceramic powder		Mice	Cementoblastic
	Human	2011	Honda et al. [53]	Pellet culture system		Rat	Osteoblastic
	Pig	2008	Tsuchiya et al. [54]	β-TCP		Mice	Osteoblastic
	Human	2005	Morsczeck et al. [10]	HA ceramic powder		Mice	Osteoblastic
	Human	2010	Yagyuu et al. [55]	Porous ceramic discs		Rat	Cementoblastic
DPSC	Dog, pig	2004	Iohara et al. [41]	Pellet culture system	BMP-2	Dog	Odontoblastic
	Human	2011	Alsanea et al. [37]	Collagen/dentin wafer	DMP-1	Mice	Odontoblastic
	Pig	2008	Prescott et al. [36]	Collagen/tooth slice	DMP-1	Mice	Odontoblastic
	Pig	2012	Kodonas et al. [44]	Collagen/PLGA		Pig	Odontoblastic
	Human	2011	Chan et al. [50]	Peptide hydrogel		Mice	Osteoblastic
	Human	2010	Demarco et al. [35]	PLLA/tooth slice and porogens		Mice	Odontoblastic
	Human	2000	Gronthos et al. [7]	HA/TCP ceramic powder		Mice	Odontoblastic
	Human	2010	Kraft et al. [51]	HA/TCP granules		Mice	Osteoblastic and odontoblastic
	Dog	2013	Wang et al. [45]	HA ceramic powder		Dog	Odontoblastic
	Dog	2013	Khorsand et al. [56]	Bovine bone granules		Dog	Osteoblastic, cementoblastic, and fibroblastic
	Rabbit	2008	El-Backly et al. [43]	DL-lactide-CO-glycolide		Rabbit	Odontoblastic
	Pig	2012	Zheng et al. [42]	β-TCP		Swine	Odontoblastic
	Rat	2013	Tsujigiwa et al. [46]	β-TCP particles		Mice	Odontoblastic
	Human	2014	Syed-Picard et al. [40]	3D scaffoldless DPSCs/root canal		Mice	Odontoblastic
	Human	2005	Laino et al. [48]	Fibrous bone obtained in vitro		Mice	Osteoblastic
	Human	2007	d’Aquino et al. [49]	Bone chips obtained in vitro		Mice	Osteoblastic
PDLSC	Dog	2012	Suaid et al. [57]	Collagen sponge		Dog	Cementoblastic and fibroblastic
	Dog	2012	Wang et al. [58]	HA ceramic particles		Mice	Fibroblastic
	Human	2004	Seo et al. [8]	HA/TCP ceramic particles		Rat	Cementoblastic and fibroblastic
	Dog	2009	Kim et al. [59]	HA/TCP granules		Dog	Osteoblastic
	Human	2011	Park et al. [60]	Macroporous biphasic calcium phosphate		Mice	Cementoblastic
	Human	2013	Ji et al. [61]	Human dentine bocks		Mice	Cementoblastic and fibroblastic
	Dog	2014	Yu et al. [62]	Bovine bone granules		Dog	Osteoblastic
	Rat	2014	Han et al. [63]	Adsorbable gelatin sponge		Rat	Osteoblastic, cementoblastic, and fibroblastic
	Human	2006	Sonoyama et al. [25]	HA/TCP blocks		Swine	Cementoblastic and fibroblastic
SHED	Human	2012	Wang et al. [64]	Ceramic bovine bone (CBB); fibrin gel		Mice	Osteoblastic
	Human	2010	Sakai et al. [65]	PLLA/tooth slice		Mice	Odontoblastic
	Human	2013	Rosa et al. [66]	Peptide hydrogel or rH collagen in root canal		Mice	Odontoblastic
	Human	2013	Alkaisi et al. [67]	Cell pellets		Rat	Osteoblastic
	Human	2014	Kim et al. [68]	Macroporous biphasic calcium phosphate	FGF-2	Mice	Odontoblastic
	Human	2010	Casagrande et al. [69]	PLLA/tooth slice		Mice	Odontoblastic
	Human	2008	Cordeiro et al. [70]	PLLA/tooth slice		Mice	Odontoblastic
	Human	2003	Miura et al. [9]	HA/TCP ceramic powder		Mice	Osteoblastic and odontoblastic
	Human	2008	Seo et al. [71]	HA/TCP particles		Mice	Osteoblastic
SCAP	Human	2006	Sonoyama et al. [25]	HA/TCP blocks		Swine	Odontoblastic
	Human	2012	Abe et al. [72]	HA/TCP particles		Mice	Osteoblastic
	Human	2010	Yagyuu et al. [55]	Porous ceramic discs		Rat	Odontoblastic