The Effect of Hydroxyl Moieties and Their Oxosubstitution on Bile Acid Association Studied in Floating Monolayers

Table 1

Solubility and CMC data of bile acids and their oxoderivatives taken from the literature.

Bile acids and oxoderivatives	Structure	Solubility mmol/L; pH3, 25^°C	CMC; mmol/L; Na-salt, 25^°C
		References [47–50]
CnA—cholanic acid; 5-cholanoic acid		No data	No data
LCA—lithocholic acid; 3-hydroxy-5-cholanoic acid		0.00005	1
DCA—deoxycholic acid; 3,12-dihydroxy-5-cholanoic acid		0.028	2–10
CDCA—chenodeoxycholic acid; 3,7-dihydroxy-5-cholanoic acid		0.027	4–9
HDCA—hyodeoxycholic acid; 3,6-dihydroxy-5-cholanoic acid		0.015	6–14
UDCA—ursodeoxycholic acid; 3,7-dihydroxy-5-cholanoic acid		0.009	7–19
3DHDCA—3-dehydrodeoxycholic acid; 3-oxo-12-hydroxy-5-cholanoic acid		No data	17
DHDCA—dehydrodeoxycholic acid; 3,12-dioxo-5-cholanoic acid		No data	51
CA—cholic acid; 3,7,12-trihydroxy-5-cholanoic acid		0.273	6–18
HCA—hyocholic acid; 3,6,7-trihydroxy-5-cholanoic acid		0.045	8–17
3DHCA—3-dehydrocholic acid; 3-oxo-7,12-dihydroxy-5-cholanoic acid		No data	98
DHCA—dehydrocholic acid; 3,7,12-trioxo-5-cholanoic acid		No data	130