PET Quantification of Cerebral Oxygen Metabolism in Small Animals
Figure 2
(Figure 1 in [15]) Quantitative values of CBF (a), OEF (b), CMRO2 (c), and cerebral metabolic rate of glucose (CMRglc) (d). PET with 15O-water and injectable 15O-O2 and an ex vivo autoradiography with 18F-FDG were performed one hour after the onset of a right middle cerebral artery occlusion using spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). CBF, OEF, and CMRO2 were obtained from PET and CMRglc was obtained from ARG. Each of the six marks indicates the hemispheric average of 4 slices in an individual. Bar-shaped marks show the average and the error bars represent SD. Significant differences between hemispheres and between SHR and WKY were determined using the Wilcoxon signed rank test, , and the Mann-Whitney test, , .
