Effect of Monotherapy and Combination Therapy of Pantoprazole and Aprepitant in Gastric Esophageal Reflux Disease in Albino Rats
Table 2
Effect of pantoprazole and aprepitant as monotherapy and combination therapy on gastric pH, volume of gastric juice, total acidity, free acidity, and esophagitis index.
S. number
Treatment (p.o)
pH
Volume of gastric juices (mL/100 g)
Total acidity (mEq/L)
Esophagitis index
Free acidity (meq/L)
Group-I
Sham control (normal saline, 3 mL/kg,)
3.27 ± 0.09
2.39 ± 0.07
30.60 ± 0.48
0.16 ± 0.02
25.86 ± 1.22
Group-II
Toxic control (normal saline, 3 mL/kg, )
2.00 ± 0.09***
3.20 ± 0.04***
55.38 ± 4.56***
3.10 ± 0.05***
42.80 ± 1.45***
Group-III
Pantoprazle (30 mg/kg)
4.00 ± 0.06***
1.68 ± 0.07*** (47.50%)
30.74 ± 3.74 (44.49%)
0.60 ± 0.02*** (80.65%)
27.14 ± 0.55 (36.59%)
Group-IV
Aprepitant (10 mg/kg)
3.28 ± 0.08
1.94 ± 0.05*** (39.38%)
39.14 ± 2.05*** (29.32%)
1.44 ± 1.08*** (53.55%)
28.38 ± 0.78** (33.69%)
Group-V
Pantoprazole + aprepitant (30 mg/kg + 10 mg/kg)
3.42 ± 0.07*
1.74 ± 0.05*** (45.63%)
32.98 ± 3.09 (40.45%)
1.16 ± 0.32*** (62.58%)
26.58 ± 0.51 (16.22%)
Each group contains six animals. Values are represented as mean ± SD. Statistical significance compared to toxic control using one-way ANOVA followed by Bonferroni test (*, **, and ***). Values in parenthesis represent percentage inhibition.
