Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2014, Article ID 187071, 8 pages
http://dx.doi.org/10.1155/2014/187071
Research Article

Pre-Conditioning with CDP-Choline Attenuates Oxidative Stress-Induced Cardiac Myocyte Death in a Hypoxia/Reperfusion Model

1Departamento de Urgencias y Unidad Coronaria, Instituto Nacional de Cardiología “Ignacio Chavez”, Juan Badiano No. 1, Colonia Seccion 16, 14080 Tlalpan, DF, Mexico
2Departamento de Neurologia, Instituto Nacional de Cardiología “Ignacio Chavez”, Juan Badiano No. 1, Colonia Seccion 16, 14080 Tlalpan, DF, Mexico
3Facultad de Medicina, Universidad Panamericana, Augusto Rodin 498, 03920 Insurgentes Mixcoac, DF, Mexico
4Departamento de Biologia Celular, Instituto Nacional de Cardiología “Ignacio Chavez”, Juan Badiano No. 1, Colonia Seccion 16, 14080 Tlalpan, DF, Mexico
5Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, UNAM, Circuito Escolar s/n, Ciudad Universitaria, 04510 Coyoacan, DF, Mexico

Received 29 August 2013; Accepted 24 October 2013; Published 21 January 2014

Academic Editors: M. Karmazyn and R. M. Mentzer

Copyright © 2014 Héctor González-Pacheco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. H. Exton, “Phosphatidylcholine breakdown and signal transduction,” Biochimica et Biophysica Acta, vol. 1212, no. 1, pp. 26–42, 1994. View at Publisher · View at Google Scholar · View at Scopus
  2. G. B. Weiss, “Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline,” Life Sciences, vol. 56, no. 9, pp. 637–660, 1995. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Zafonte, W. T. Friedewald, S. M. Lee et al., “The citicoline brain injury treatment (COBRIT) trial: design and methods,” Journal of Neurotrauma, vol. 26, no. 12, pp. 2207–2216, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Ortega, C. Jacas, M. Quintana et al., “Citicoline treatment prevents neurocognitive decline after a first ischemic stroke,” Cerebrovascular Diseases, vol. 29, supplement 2, p. 268, 2010. View at Google Scholar
  5. J. L. Saver, “Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair,” Reviews in Neurological Diseases, vol. 5, no. 4, pp. 167–177, 2008. View at Google Scholar · View at Scopus
  6. H. J. Cho and Y. J. Kim, “Efficacy and safety of oral citicoline in acute ischemic stroke: drug surveillance study in 4,191 cases,” Methods and Findings in Experimental and Clinical Pharmacology, vol. 31, no. 3, pp. 171–176, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. P. C. Choy, M. Chan, G. Hatch, and R. Y. K. Man, “Phosphatidylcholine metabolism in ischemic and hypoxic hearts,” Molecular and Cellular Biochemistry, vol. 116, no. 1-2, pp. 53–58, 1992. View at Publisher · View at Google Scholar · View at Scopus
  8. C. P. Baines, “How and when do myocytes die during ischemia and reperfusion: the late phase,” Journal of Cardiovascular Pharmacology and Therapeutics, vol. 16, no. 3-4, pp. 239–243, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. T. L. Vanden Hoek, C. Li, Z. Shao, P. T. Schumacker, and L. B. Becker, “Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion,” Journal of Molecular and Cellular Cardiology, vol. 29, no. 9, pp. 2571–2583, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Vinten-Johansen, “Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury,” Cardiovascular Research, vol. 61, no. 3, pp. 481–497, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. S. B. Haudek, G. E. Taffet, M. D. Schneider, and D. L. Mann, “TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways,” Journal of Clinical Investigation, vol. 117, no. 9, pp. 2692–2701, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. K. R. Pitts and C. F. Toombs, “Coverslip hypoxia: a novel method for studying cardiac myocyte hypoxia and ischemia in vitro,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 287, no. 4, pp. H1801–H1812, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. O. Hurtado, A. Cárdenas, J. M. Pradillo et al., “A chronic treatment with CDP-choline improves functional recovery and increases neuronal plasticity after experimental stroke,” Neurobiology of Disease, vol. 26, no. 1, pp. 105–111, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Bolli, M. O. Jeroudi, B. S. Patel et al., “Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog,” Proceedings of the National Academy of Sciences of the United States of America, vol. 86, no. 12, pp. 4695–4699, 1989. View at Google Scholar · View at Scopus
  15. G. W. Mergner, W. B. Weglicki, and J. H. Kramer, “Postischemic free radical production in the venous blood of the regionally ischemic swine heart. Effect of deferoxamine,” Circulation, vol. 84, no. 5, pp. 2079–2090, 1991. View at Google Scholar · View at Scopus
  16. H. P. Grill, J. L. Zweier, P. Kuppusamy, M. L. Weisfeldt, and J. T. Flaherty, “Direct measurement of myocardial free radical generation in an in vivo model: effects of postischemic reperfusion and treatment with human recombinant superoxide dismutase,” Journal of the American College of Cardiology, vol. 20, no. 7, pp. 1604–1611, 1992. View at Google Scholar · View at Scopus
  17. G. Itoh, J. Tamura, M. Suzuki et al., “DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis,” The American Journal of Pathology, vol. 146, no. 6, pp. 1325–1331, 1995. View at Google Scholar · View at Scopus
  18. T. M. Scarabelli, A. Stephanou, E. Pasini et al., “Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury,” Circulation Research, vol. 90, no. 6, pp. 745–748, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. J. L. Zweier and M. A. H. Talukder, “The role of oxidants and free radicals in reperfusion injury,” Cardiovascular Research, vol. 70, no. 2, pp. 181–190, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Maulik, T. Yoshida, and D. K. Das, “Oxidative stress developed during the reperfusion of ischemic myocardium induces apoptosis,” Free Radical Biology and Medicine, vol. 24, no. 5, pp. 869–875, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Maulik, V. E. Kagan, V. A. Tyurin, and D. K. Das, “Redistribution of phosphatidylethanolamine and phosphatidylserine precedes reperfusion-induced apoptosis,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 274, no. 1, pp. H242–H248, 1998. View at Google Scholar · View at Scopus
  22. C. C. Hsieh, M. H. Yen, H. W. Liu, and Y. T. Lau, “Lysophosphatidylcholine induces apoptotic and non-apoptotic death in vascular smooth muscle cells: in comparison with oxidized LDL,” Atherosclerosis, vol. 151, no. 2, pp. 481–491, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Kakisaka, S. C. Cazanave, C. D. Fingas et al., “Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis,” The American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 302, no. 1, pp. G77–G84, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Mulder, L. O. Wahlund, T. Teerlink et al., “Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer's disease,” Journal of Neural Transmission, vol. 110, no. 8, pp. 949–955, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. R. M. Adibhatla, J. F. Hatcher, and R. J. Dempsey, “Cytidine-5′-diphosphocholine affects CTP-phosphocholine cytidylyltransferase and lyso-phosphatidylcholine after transient brain ischemia,” Journal of Neuroscience Research, vol. 76, no. 3, pp. 390–396, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. C. Kent, “CTP:phosphocholine cytidylyltransferase,” Biochimica et Biophysica Acta, vol. 1348, no. 1-2, pp. 79–90, 1997. View at Publisher · View at Google Scholar · View at Scopus
  27. R. M. Adibhatla and J. F. Hatcher, “Cytidine 5′-diphosphocholine (CDP-choline) in stroke and other CNS disorders,” Neurochemical Research, vol. 30, no. 1, pp. 15–23, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Neidhardt, Y. Costes, K. Bachour, and N. Platonoff, “Effect of cytidine diphosphate choline on anoxia tolerance of cultured myocardial cells,” Clinical Therapeutics, vol. 14, no. 4, pp. 537–543, 1992. View at Google Scholar · View at Scopus