Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2014 (2014), Article ID 189824, 6 pages
http://dx.doi.org/10.1155/2014/189824
Research Article

Evaluation of Halogenated Coumarins for Antimosquito Properties

1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia
2Department of Biotechnology and Food Technology, Durban University of Technology, Durban 4001, South Africa
3CREAN-IMBIV (CONICET-UNC), Facultad de Ciencias Agropecuarias, and FCEFyN, Universidad Nacional de Córdoba, Avenida Valparaíso s/n, 5016 Córdoba, Argentina

Received 26 August 2014; Accepted 2 December 2014; Published 25 December 2014

Academic Editor: Valdir Cechinel Filho

Copyright © 2014 Venugopala K. Narayanaswamy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mosquitoes are the major vectors of parasites and pathogens affecting humans and domestic animals. The widespread development of insecticide resistance and negative environmental effects of most synthetic compounds support an interest in finding and developing alternative products against mosquitoes. Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being insecticidal. In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for larvicidal, adulticidal, and repellent properties against Anopheles arabiensis, a zoophilic mosquito that is one of the dominant vectors of malaria in Africa. Five compounds exerted 100% larval mortality within 24 h of exposure. All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. Repellent properties could not be evidenced. Five compounds were considered potential larvicidal agents for further research and development, while adulticidal activity was considered only mild to moderate.