Preliminary Anticonvulsant and Toxicity Screening of Substituted Benzylidenehydrazinyl-N-(6-substituted benzo[d]thiazol-2-yl)propanamides

Table 1

Physicochemical parameters of the synthesized compounds (5a–t).

Compound	R	R′	Molecular formula		Log^b	M.P (°C)
5a	Cl	H	C17H15ClN4OS	4.32	4.14	192–194	0.42
5b	F	H	C17H15FN4OS	3.92	3.57	188–190	0.35
5c	CH3	H	C18H18N4OS	4.24	3.92	130–132	0.81
5d	OCH3	H	C18H18N4O2S	3.63	3.72	202–204	0.32
5e	Cl	2-OH	C17H15ClN4O2S	3.93	4.73	198–200	0.59
5f	F	2-OH	C17H15FN4O2S	3.53	3.53	164–166	0.44
5g	CH3	2-OH	C18H18N4O2S	3.86	4.46	180–182	0.61
5h	OCH3	2-OH	C18H18N4O3S	3.24	4.32	110–112	0.78
5i	Cl	4-OH	C17H15ClN4O2S	3.95	4.76	210–212	0.31
5j	F	4-OH	C17H15FN4O2S	3.59	3.61	201–203	0.48
5k	CH3	4-OH	C18H18N4O2S	3.89	3.97	185–187	0.62
5l	OCH3	4-OH	C18H18N4O3S	3.24	4.32	117–119	0.57
5m	Cl	4-CH3	C18H17ClN4OS	4.8	4.61	175-176	0.65
5n	F	4-CH3	C18H17FN4OS	4.44	4.06	190–192	0.4
5o	CH3	4-CH3	C19H20N4OS	4.73	4.44	205-206	0.71
5p	OCH3	4-CH3	C19H20N4O2S	4.12	4.22	200-201	0.6
5q	Cl	4-OCH3	C18H17ClN4O2S	4.19	4.42	140–142	0.55
5r	F	4-OCH3	C18H17FN4O2S	3.79	3.85	169–171	0.43
5s	CH3	4-OCH3	C19H20N4O2S	4.12	4.20	161–163	0.38
5t	OCH3	4-OCH3	C19H20N4O3S	4.75	4.41	215–217	0.54

Solvent of crystallization-ethanol. was calculated using octanol-phosphate buffer. Log was calculated using software chem. Draw ultra 8. ^cSolvent system-toluene : ethyl acetate : formic acid (5 : 4 : 1), benzene : acetone (8 : 2).