Research Article
Differences in Risk Factors for Retinopathy of Prematurity Development in Paired Twins: A Chinese Population Study
Table 1
Univariate and multivariate analysis of maternal and natal covariates for ROP development in twin pairs.
| | | Univariate logistic analysis | Multivariate logistic analysis | | | Twin 1 | Twin 2 | Twin 1 | Twin 2 | | | Odds ratio | Coefficient estimates | value | Odds ratio | Coefficient estimates | value | Odds ratio | Coefficient estimates | value | Odds ratio | Coefficient estimates | value |
| | Gender (male versus female) | 1.22 | 0.20 | 0.84 | 0.67 | −0.41 | 0.70 | 0.99 | −0.01 | 0.71 | 1.00 | 0.00 | 0.92 | | Gestational age | 0.44 | −0.82 | 0.02* | 0.45 | −0.79 | 0.03* | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Birth weight | 1.00 | 0.00 | 0.10 | 1.00 | 0.00 | 0.09 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Preeclampsia | 0.01 | −4.29 | 0.29 | 0.02 | −3.93 | 1.00 | 1.00 | 0.00 | 0.98 | 1.00 | 0.00 | 1.00 | | Gestational diabetes mellitus | 2.17 | 0.77 | 0.54 | 1.67 | 0.51 | 0.68 | 1.00 | 0.00 | 0.97 | 1.00 | 0.00 | 1.00 | | In vitro fertilization | 1.09 | 0.09 | 0.93 | 2.00 | 0.69 | 0.52 | 1.00 | 0.00 | 0.96 | 1.00 | 0.00 | 1.00 | | Postnatal hypotension | 3.37 | 1.22 | 0.36 | 0.02 | −3.93 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.99 | | Inotropes use | 7.00 | 1.95 | 0.20 | 9.67 | 2.27 | 0.14 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 1.00 | | Antenatal steroid use | 76.10 | 4.33 | 1.00 | 50.51 | 3.92 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Apgar score 1 min | 0.75 | −0.28 | 0.24 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 1.00 | | Apgar score 5 min | 0.71 | −0.34 | 0.30 | 1.16 | 0.15 | 0.75 | 1.00 | 0.00 | 0.96 | 1.00 | 0.00 | 1.00 | | Apgar score 10 min | 0.51 | −0.67 | 0.13 | 2.09 | 0.74 | 0.48 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Respiratory distress syndrome | 85.99 | 4.45 | 1.00 | 53.82 | 3.99 | 1.00 | 1.00 | 0.00 | 0.75 | 1.00 | 0.00 | 0.98 | | Bronchopulmonary dysplasia | 2.10 | 0.74 | 0.46 | 1.33 | 0.29 | 0.82 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Surfactant use | 85.99 | 4.45 | 1.00 | 53.82 | 3.99 | 1.00 | 1.00 | 0.00 | 0.75 | 1.00 | 0.00 | 0.98 | | Invasive mechanical ventilation | 4.71 | 1.55 | 0.13 | 2.33 | 0.85 | 0.43 | 1.00 | 0.00 | 0.95 | 1.00 | 0.00 | 1.00 | | Oxygen supplement | 0.14 | −1.95 | 0.20 | 50.51 | 3.92 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Mean oxygen concentration | 1.34 | 0.29 | 0.03* | 0.95 | −0.05 | 0.72 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 0.99 | | Congenital heart disease | 1.56 | 0.45 | 0.72 | 2.00 | 0.69 | 0.52 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 0.99 | | Patent ductus arteriosus | 5.75 | 1.75 | 0.09 | 3.92 | 1.37 | 0.26 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | NSAID use | 5.78 | 1.75 | 0.11 | 0.92 | −0.09 | 0.94 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Anemia | 177.43 | 5.18 | 1.00 | 0.78 | −0.25 | 0.84 | 1.00 | 0.00 | 0.98 | 1.00 | 0.00 | 1.00 | | Thrombocytopenia | 1429.60 | 7.27 | <0.0001* | 0.02 | −3.93 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Blood transfusion | 10.50 | 2.35 | 0.05 | 0.92 | −0.09 | 0.94 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 1.00 | | Intraventricular hemorrhage | 18.67 | 2.93 | 0.03* | 0.02 | −3.99 | 0.26 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 1.00 | | Necrotizing colitis | 0.01 | −4.31 | 0.09 | 9.67 | 2.27 | 0.14 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Neonatal jaundice | 1.27 | 0.24 | 0.84 | 0.25 | −1.39 | 0.21 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Phototherapy | 1.52 | 0.42 | 0.72 | 0.30 | −1.19 | 0.27 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Total parenteral nutrition | 2.10 | 0.74 | 0.46 | 1.33 | 0.29 | 0.82 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 1.00 | | Hypoglycemia | 0.83 | −0.18 | 0.88 | 50.51 | 3.92 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Sepsis | 0.96 | −0.04 | 0.97 | 0.78 | −0.25 | 0.84 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Meningitis | 0.56 | −0.59 | 0.62 | 2.17 | 0.77 | 0.54 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.98 | | Preterm premature rupture of membrane | 0.41 | −0.89 | 0.45 | 2.00 | 0.69 | 0.52 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Acidosis | 0.71 | −0.34 | 0.73 | 1.33 | 0.29 | 0.82 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 |
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Statistically significant.
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