Research Article
Differences in Risk Factors for Retinopathy of Prematurity Development in Paired Twins: A Chinese Population Study
Table 2
Univariate and multivariate analysis of maternal and natal covariates for Type 1 ROP development in twin pairs.
| | | Univariate logistic analysis | Multivariate logistic analysis | | | Twin 1 | Twin 2 | Twin 1 | Twin 2 | | | Odds ratio | Coefficient estimates | value | Odds ratio | Coefficient estimates | value | Odds ratio | Coefficient estimates | value | Odds ratio | Coefficient estimates | value |
| | Gender (male versus female ) | 31.51 | 3.45 | 1.00 | 0.07 | −2.64 | 1.00 | 1.01 | 0.01 | 1.00 | 1.00 | 0.00 | 1.00 | | Gestational age | 0.26 | −1.33 | 0.16 | 0.70 | −0.36 | 1.00 | 1.01 | 0.01 | 1.00 | 0.99 | −0.01 | 1.00 | | Birth weight | 1.00 | 0.00 | 0.27 | 0.99 | −0.01 | 0.17 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Preeclampsia | 0.04 | −3.15 | 1.00 | 0.04 | −3.15 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.98 | | Gestational diabetes mellitus | 0.05 | −2.95 | 1.00 | 44.08 | 3.79 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.97 | | In vitro fertilization | 19.39 | 2.96 | 1.00 | 25.34 | 3.23 | 1.00 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 0.96 | | Postnatal hypotension | 0.04 | −3.15 | 1.00 | 0.04 | −3.15 | 1.00 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 1.00 | | Inotrope use | 0.03 | −3.51 | 1.00 | 314.19 | 5.75 | 1.00 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 0.99 | | Antenatal steroid use | 17.29 | 2.85 | 1.00 | 19.16 | 2.95 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.99 | | Apgar score 1 min | 0.29 | −1.24 | 0.20 | 0.84 | −0.17 | 0.71 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.97 | | Apgar score 5 min | 0.49 | −0.71 | 0.23 | 0.42 | −0.86 | 0.19 | 1.00 | 0.00 | 0.98 | 1.00 | 0.00 | 0.96 | | Apgar score 10 min | 0.68 | −0.38 | 0.64 | 0.36 | −1.02 | 0.44 | 1.00 | 0.00 | 0.97 | 1.00 | 0.00 | 0.94 | | Respiratory distress syndrome | 17.04 | 2.84 | 1.00 | 16.62 | 2.81 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Bronchopulmonary dysplasia | 0.06 | −2.87 | 1.00 | 58.74 | 4.07 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Surfactant use | 17.04 | 2.84 | 1.00 | 16.62 | 2.81 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Invasive mechanical ventilation | 45.38 | 3.82 | 1.00 | 33.64 | 3.52 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.98 | | Oxygen supplement | 33.56 | 3.51 | 1.00 | 19.16 | 2.95 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.98 | | Mean oxygen concentration | 1.39 | 0.33 | 0.18 | 0.86 | −0.15 | 0.62 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Congenital heart disease | 63.09 | 4.14 | 1.00 | 25.34 | 3.23 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Patent ductus arteriosus | 61.68 | 4.12 | 1.00 | 9.51 | 2.25 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.99 | | NSAID use | 0.06 | −2.85 | 1.00 | 61.68 | 4.12 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.99 | | Anemia | 15.06 | 2.71 | 1.00 | 45.38 | 3.82 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Thrombocytopenia | 0.01 | −4.98 | 1.00 | 0.04 | −3.15 | 1.00 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 0.99 | | Blood transfusion | 25.34 | 3.23 | 1.00 | 61.68 | 4.12 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.99 | | Intraventricular hemorrhage | 161.31 | 5.08 | 1.00 | 0.03 | −3.51 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Necrotizing colitis | 0.03 | −3.51 | 1.00 | 0.03 | −3.51 | 1.00 | 1.00 | 0.00 | 0.99 | 1.00 | 0.00 | 0.98 | | Neonatal jaundice | 17.04 | 2.84 | 1.00 | 0.03 | −3.52 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Phototherapy | 17.84 | 2.88 | 1.00 | 0.02 | −3.98 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Total parenteral nutrition | 0.06 | −2.87 | 1.00 | 58.74 | 4.07 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Hypoglycemia | 16.62 | 2.81 | 1.00 | 19.16 | 2.95 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 0.99 | | Sepsis | 0.06 | −2.81 | 1.00 | 45.38 | 3.82 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Meningitis | 45.38 | 3.82 | 1.00 | 0.06 | −2.85 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Preterm premature rupture of membrane | 0.05 | −3.09 | 1.00 | 25.34 | 3.23 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 | | Acidosis | 0.03 | −3.52 | 1.00 | 0.06 | −2.81 | 1.00 | 1.00 | 0.00 | 1.00 | 1.00 | 0.00 | 1.00 |
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