A Chinese Herbal Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats

Table 3

Inhibitory effects of various doses of JWXYS on FeCl₂-induced (in vitro) and DMN-induced (in vivo) lipid peroxidation in rat livers.

Group		MDA; (nmole/mg protein)	Inhibition rate (%)
A	Normal control	1.69 ± 0.11
In vitro
B	FeCl2	2.63 ± 0.08**
C	FeCl2 + vitamin E (0.5 mM)	0.76 ± 0.05^##	71.10
D	FeCl2 + JWXYS (0.1 mg/kg)	2.10 ± 0.05^##	20.15
E	FeCl2 + JWXYS (1.0 mg/kg)	1.44 ± 0.06^##	45.25
F	FeCl2 + JWXYS (10 mg/kg)	1.27 ± 0.03^###	51.71
In vivo
G	DMN	3.71 ± 0.05**
H	DMN + vitamin E (0.69 mM)	1.07 ± 0.05^△△△	71.16
I	DMN + JWXYS (100 mg/kg)	2.79 ± 0.05^△△	24.80
J	DMN + JWXYS (300 mg/kg)	2.21 ± 0.06^△△	40.43
K	DMN + JWXYS (1000 mg/kg)	1.15 ± 0.03^△△△	69.00

Each value is presented as the mean ± SE (𝑛=6). Vitamin E was used as the positive control.
** 𝑃<0.01, significantly different from Group A.
^##,###𝑃<0.01 and 0.001, significantly different from Group B.
^{△△,△△△}𝑃<0.01 and 0.001, significantly different from Group G.
One-way analysis of variance coupled with Dunnett’s test.
P values < 0.05 indicated significance.