Physicochemical Characterization and Thermodynamic Studies of Nanoemulsion-Based Transdermal Delivery System for Fullerene

Table 6

Accelerated stability assessment of the Pre-F and FNEs.

Formulation	Centrifugation test at 4000 rpm for 15 min	298 K	318 K	Freeze-thaw cycles
Pre-F	✗	—	—	✗
FNE1	✗	—	—	✗
FNE2
(a)	✓	✓	✗	✓
(b)	✓	✓	✗	✓
(c)	✓	✓	✓	✓
(d)	✓	✓	✓	✓
(e)	✓	✓	✓	✓
FNE3
(a)	✓	✓	✗	✓
(b)	✓	✓	✗	✓
(c)	✓	✓	✓	✓
(d)	✓	✓	✓	✓
(e)	✓	✓	✓	✓
FNE4
(a)	✓	✓	✗	✓
(b)	✓	✓	✗	✓
(c)	✓	✓	✓	✓
(d)	✓	✓	✓	✓
(e)	✓	✓	✓	✓
FNE5
(a)	✓	✓	✗	✓
(b)	✓	✓	✗	✓
(c)	✓	✓	✓	✓
(d)	✓	✓	✓	✓
(e)	✓	✓	✓	✓

Note: ✓,stable (without phase separation); ✗, unstable (with phase separation).