Design, Synthesis, and In Vitro Kinetics Study of Atenolol Prodrugs for the Use in Aqueous Formulations

Table 2

First-order hydrolysis plot of atenolol ProD 1 in (a) 1N HCl, (b) buffer pH 2, and (c) buffer pH 5.

Medium	𝑘obs (hours^−1)	𝑡1/2 (hours)
1N HCl	4.95×10^−4	2.53
Buffer pH 2	2.22×10^−4	3.82
Buffer pH 5	2.75×10^−6	133
Buffer pH 7.4	—	—