| Conventional delivery system | Drug | Side effects | Reference |
| Lotion | Benzoyl peroxide | Peeling, itching, redness, dryness, burning, and dermatitis | [41] | Clindamycin | Peeling, itching, redness, dryness | [42] | Tretinoin | Erythema, scaling, burning | [43] | Erythromycin | Erythema, scaling, burning | [44] | Glycolic acid | Itching, rash, pruritus | [45] | Tretinoin | Itching, rash, pruritus | [45] |
| Cream | Adapalene | Erythema, scaling, dryness, burning, stinging, irritation, sunburn | [46] | Tazarotene | Erythema, scaling, burning | [47] | Azelaic acid | Itching, rash, pruritus | [45] | Tea oil | Burning, itching, irritation, stinging | [48] | Clindamycin | Erythema, desquamation | [49] |
| Gel | Salicylic acid | Erythema, dryness, dermatitis | [41, 50] | Erythromycin | Dryness, erythema, peeling, dermatitis | [44, 51] | Benzoyl peroxide | Dryness, erythema, peeling, dermatitis | [51] | Adapalene | Erythema, scaling, dryness, burning, stinging, irritation | [46] | Dapsone | Peeling, itching, redness, burning | [52] |
| Emollient | Sodium sulfacetamide-sulfur | Dryness, irritation, redness, scaling, stinging, or burning | [53] |
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