Preparation and Evaluation of Novel In Situ Gels Containing Acyclovir for the Treatment of Oral Herpes Simplex Virus Infections

Table 2

Composition of the drug loaded formulations containing glycerin.

FC	Drug (gm)	Glycerin (mL)	P407 (gm)	P188 (gm)	C934 (gm)	HPMC K-100 (gm)	MP (gm)	PP (gm)	D/W (mL)
Fg1	0.6	6	6	—	—	0.15	0.03	0.003	30
Fg2	0.6	6	4	2	—	0.15	0.03	0.003	30
Fg3	0.6	6	4.5	—	0.09	0.15	0.03	0.003	30
Fg4	0.6	6	6	—	0.03	0.15	0.03	0.003	30
Fg5	0.6	6	6	—	0.09	0.15	0.03	0.003	30
Fg6	0.6	6	6	—	0.15	0.15	0.03	0.003	30

Note: FC: formulation code, Gly: glycerin, P407: poloxamer 407, P188: poloxamer188, C934: carbopol934, HPMC K-100: hydroxypropyl methyl cellulose, MP: methyl paraben, PP: propyl paraben, and D/W: distilled water.