Preparation and Evaluation of Novel In Situ Gels Containing Acyclovir for the Treatment of Oral Herpes Simplex Virus Infections

Table 3

Solubility of acyclovir in different pH buffer solutions.

S. no.	Buffer solution	Solubility (microg/mL)
1	HCl buffer of pH1.2	18.315
2	Acetate buffer of pH4.5	10.064
3	Phosphate buffer of pH5.5	2.515
4	Phosphate buffer of pH6.8	2.25
5	Phosphate buffer of pH7.4	2.558
6	Borate buffer of pH9.8	61.842