Preparation and Evaluation of Novel In Situ Gels Containing Acyclovir for the Treatment of Oral Herpes Simplex Virus Infections

Table 4

Evaluation data 1 of in situ gel formulation.

FC	𝑇sol-gel	Gelling capacity	Appearance		pH
			Solution state	Gel state	Observed	Adjusted to
Ft1	31.333 ± 1.155	++	√	€	8.15	7
Ft2	35.333 ± 1.145	++	√	€	8.21	7
Ft3	35.333 ± 0.577	++	√	€	5.6	5.8
Ft4	38.666 ± 1.154	++	√	€€	5.78	5.8
Ft5	35.666 ± 0.577	++	√ √	€€	5.34	5.8
Ft6	29.666 ± 1.154	+++	√ √√	€€€	5.56	5.8
Fg1	28.333 ± 0.577	++	∆	○	8.13	7
Fg2	34.666 ± 1.527	++	∆	○	8.18	7
Fg3	37.666 ± 0.577	++	∆	○	5.17	5.8
Fg4	35.333 ± 0.577	++	∆	○○	5.65	5.8
Fg5	31.333 ± 1.155	++	∆∆	○○	5.48	5.8
Fg6	30.333 ± 0.577	+++	∆∆∆	○○	5.63	5.8

+: gel after few minutes dissolves rapidly.
++: immediate gelation remains for few mins.
+++: immediate gelation remains for nearly an hr.
√: yellowish solution with less viscosity.
√ √: yellowish solution with moderate viscosity.
√ √√: yellowish solution with high viscosity.
∆: white colored solution with less viscosity.
∆∆: white colored solution with moderate viscosity.
∆∆∆: white colored solution with high viscosity.
FC: formulation code.
€: yellowish semifluid gel.
€€: yellow colored semistiff gel.
€€€: yellow colored stiff gel.
○: white colored semistiff gel.
○○: white colored stiff gel.