Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells

Table 1

Risk factors for gonadal damage.

	Risk factor degree
Patient relating factor
Pubertal stage	Postpuberal >prepuberal
Age of HSCT in women	>30 years
Sex	F > M
Underlying disease	ALL, lymphomas
Treatment relating factor
Type of radiotherapy	TBI, pelvic, inverted Y, fractionated doses
Chemotherapy	Alkylating agents > other chemotherapy
Type of transplant	Previous TBI; Allo-HSCT >auto-HSCT
HSCT complications	Presence of GVHD

ALL: acute lymphoblastic leukemia; allo: allogeneic; auto: autologous; GVHD: graft-versus-host disease; HSCT: hematopoietic stem cell transplant; F: female; M: male; TBI: “total body” irradiation.
Symbol (>) means more than.