Optimization of Ionic Liquid Based Simultaneous Ultrasonic- and Microwave-Assisted Extraction of Rutin and Quercetin from Leaves of Velvetleaf (Abutilon theophrasti) by Response Surface Methodology

Table 1

Central composite design (CCD) of independent variables for process optimization.

Run	Coded			Actual
	Factor A; )	Factor B; )	Factor C; )	Time,; min )	Liquid-solid ratio,; mL/g )	Microwave power,; W )
1	1	−1	1	14	20	700
2	−1	−1	1	6	20	700
3	0	0	0	10	30	500
4	−1	1	1	6	40	700
5	0	0	1.68	10	30	836.36
6	1.68	0	0	16.73	30	500
7	1	1	1	14	40	700
8	0	0	0	10	30	500
9	−1	−1	−1	6	20	300
10	1	1	−1	14	40	300
11	0	0	0	10	30	500
12	0	0	−1.68	10	30	163.64
13	−1	1	−1	6	40	300
14	1	−1	−1	14	20	300
15	0	0	0	10	30	500
16	0	0	0	10	30	500
17	0	−1.68	0	10	13.18	500
18	0	0	0	10	30	500
19	0	1.68	0	10	46.82	500
20	−1.68	0	0	3.27	30	500