Review Article

Current State of Evidence for Medication Treatment of Preschool Internalizing Disorders

Table 1

Characteristics of identified studies.

Author(s)Publication yearDiagnoses addressedMedication(s) and participant characteristics DesignConcurrent treatmentTreatment measures

Avci et al. [31]1998Specific PhobiaFluoxetine (SSRI) Female
Age: 2.5
Case studyNoneNone
Carlson et al. [33] 1999Selective MutismSertraline (SSRI) Females and 1 Male
Ages: 5
Single case designNoneGAS, CBCL, CGI, PQ, TRS, TEQ-P
Coskun and Zoroglu [29]2009Obsessive Compulsive Disorder Fluoxetine (SSRI) Females and 3 Males
Ages: 3–5
Quasi-experimental designRisperidone ( )
Hydroxyzine ( )
CGI-S
Celik et al. [32]2007Posttraumatic Eating Disorder/fear of feedingFluoxetine (SSRI) Females
Ages: 2
Case studyBehavior therapy None
Dummit III et al. [25]1996Selective MutismFluoxetine (SSRI) Females and 2 Males
Age: 5
Quasi-experimental designSupportive psychotherapyCGI
Ercan et al. [30]2012Obsessive Compulsive DisorderFluoxetine (SSRI) Females and 1 Male
Ages: 2–5
Case studyNoneCGI
CY-BOCS
Golwyn and Sevlie [26] 1999Selective MutismPhenelzine (MAO-I) Fluoxetine (SSRI) Female
Age: 4
Case studyClonazepam in combination with Phenelzine (Insomnia)None
Harvey and Milne [27]1998Selective MutismFluoxetine (SSRI) Female
Age: 5
Case studyBehavioral, family, and psychodynamic therapy; individual therapy for child; individual therapy for family members; occupational therapy; psychoeducation None
Hanna et al. [36] 1997Feeding Disorder of Infancy and Early Childhood/Anxiety Buspirone (Azapirone) Male
Age: 4
Case studyNoneNone
O. Oner and P. Oner [34]2008Obsessive Compulsive Disorder Sertraline (SSRI) Females
Ages: 4-5
Case studyRisperidone ( )CY-BOCS
Wright et al. [28]1995Selective MutismFluoxetine (SSRI) Female
Age: 4
Case studySchool based behavioral intervention, behavior therapy, family therapyCBCL, PSI, VABS