Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2014, Article ID 293190, 7 pages
http://dx.doi.org/10.1155/2014/293190
Research Article

Inducing Effect of Dihydroartemisinic Acid in the Biosynthesis of Artemisinins with Cultured Cells of Artemisia annua by Enhancing the Expression of Genes

1Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China
2College of Pharmacy, Jinan University, Guangzhou 510632, China

Received 7 February 2014; Accepted 6 July 2014; Published 17 July 2014

Academic Editor: Harrie Verhoeven

Copyright © 2014 Jianhua Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. López, C. Saravia, A. Gomez, J. Hoebeke, and M. A. Patarroyo, “Mechanisms of genetically-based resistance to malaria,” Gene, vol. 467, no. 1-2, pp. 1–12, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. A. G. Blazquez, M. Fernandez-Dolon, L. Sanchez-Vicente et al., “Novel artemisinin derivatives with potential usefulness against liver/colon cancer and viral hepatitis,” Bioorganic and Medicinal Chemistry, vol. 21, no. 14, pp. 4432–4441, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. G. D. Brown, “The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao),” Molecules, vol. 15, no. 11, pp. 7603–7698, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. C. J. Paddon, P. J. Westfall, D. J. Pitera et al., “High-level semi-synthetic production of the potent antimalarial artemisinin,” Nature, vol. 496, no. 7446, pp. 528–532, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Kjær, F. Verstappen, H. Bouwmeester et al., “Artemisinin production and precursor ratio in full grown Artemisia annua L. plants subjected to external stress,” Planta, vol. 237, no. 4, pp. 955–966, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Ro, E. M. Paradise, M. Quellet et al., “Production of the antimalarial drug precursor artemisinic acid in engineered yeast,” Nature, vol. 440, no. 7086, pp. 940–943, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. P. S. Covello, “Making artemisinin,” Phytochemistry, vol. 69, no. 17, pp. 2881–2885, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. L. A. Graham, K. Besser, S. Blumer et al., “The genetic map of Artemisia annua L identifies loci affecting yield of the antimalarial drug artemisinin,” Science, vol. 327, no. 5963, pp. 328–331, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. J. D. Newman and J. Chappell, “Isoprenoid biosynthesis in plants: carbon partitioning within the cytoplasmic pathway,” Critical Reviews in Biochemistry and Molecular Biology, vol. 34, no. 2, pp. 95–106, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. H. J. Bouwmeester, T. E. Wallaart, M. H. A. Janssen et al., “Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis,” Phytochemistry, vol. 52, no. 5, pp. 843–854, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. K. H. Teoh, D. R. Polichuk, D. W. Reed, G. Nowak, and P. S. Covello, “Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin,” FEBS Letters, vol. 580, no. 5, pp. 1411–1416, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Zhang, K. H. Teoh, D. W. Reed et al., “The molecular cloning of artemisinic aldehyde 11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua,” The Journal of Biological Chemistry, vol. 283, no. 31, pp. 21501–21508, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. K. H. Teoh, D. R. Polichuk, D. W. Reed, and P. S. Covello, “Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua,” Botany, vol. 87, no. 6, pp. 635–642, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Sy and G. D. Brown, “The mechanism of the spontaneous autoxidation of dihydroartemisinic acid,” Tetrahedron, vol. 58, no. 5, pp. 897–908, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Schramek, H. Wang, W. Römisch-Margl et al., “Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study,” Phytochemistry, vol. 71, no. 2-3, pp. 179–187, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. G. D. Brown and L. K. Sy, “In vivo transformations of dihydroartemisinic acid in Artemisia annua plants,” Tetrahedron, vol. 60, no. 5, pp. 1139–1159, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Baldi and V. K. Dixit, “Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua,” Bioresource Technology, vol. 99, no. 11, pp. 4609–4614, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Zeng, F. Yan, L. Tang, and F. Chen, “Increased crocin production and induction frequency of stigma-like-structure from floral organs of Crocus sativus by precursor feeding,” Plant Cell, Tissue and Organ Culture, vol. 72, no. 2, pp. 185–191, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. T. E. Wallaart, W. Van Uden, H. G. M. Lubberink, H. J. Woerdenbag, N. Pras, and W. J. Quax, “Isolation and identification of dihydroartemisinic acid from Artemisia annua and its possible role in the biosynthesis of artemisinin,” Journal of Natural Products, vol. 62, no. 3, pp. 430–433, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. W. Wen, J. H. Zhu, J. W. Liu, and R. M. Yu, “Impact of artemisinic acid on the growth and catharanthine production in Catharanthus roseus cell culture,” Journal of Medicinal Plants Research, vol. 6, no. 10, pp. 2019–2028, 2012. View at Google Scholar
  21. F. Jing, L. Zhang, M. Li et al., “Abscisic acid (ABA) treatment increases artemisinin content in Artemisia annua by enhancing the expression of genes in artemisinin biosynthetic pathway,” Biologia, vol. 64, no. 2, pp. 319–323, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. L. K. Sy, G. D. Brown, and R. Haynes, “A novel endoperoxide and related sesquiterpenes from Artemisia annua which are possibly derived from allylic hydroperoxides,” Tetrahedron, vol. 54, no. 17, pp. 4345–4356, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. Z. X. Yu, J. X. Li, C. Q. Yang, W. L. Hu, L. J. Wang, and X. Y. Chen, “The jasmonate-responsive AP2/ERF transcription factors AaERF1 and AaERF2 positively regulate artemisinin biosynthesis in Artemisia annua L.,” Molecular Plant, vol. 5, no. 2, pp. 353–365, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. M. P. Arvy, N. Imbault, F. Naudascher, M. Thiersault, and P. Doireau, “2,4-D and alkaloid accumulation in periwinkle cell suspensions,” Biochimie, vol. 76, no. 5, pp. 410–416, 1994. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Hedhili, V. Courdavault, N. Giglioli-Guivarc'h, and P. Gantet, “Regulation of the terpene moiety biosynthesis of Catharanthus roseus terpene indole alkaloids,” Phytochemistry Reviews, vol. 6, no. 2-3, pp. 341–351, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Hong, W. Hu, J. Li, X. Chen, and L. Wang, “Increased accumulation of artemisinin and anthocyanins in Artemisia annua expressing the arabidopsis blue light receptor CRY1,” Plant Molecular Biology Reporter, vol. 27, no. 3, pp. 334–341, 2009. View at Publisher · View at Google Scholar · View at Scopus