Association between a Variant in MicroRNA-646 and the Susceptibility to Hepatocellular Carcinoma in a Large-Scale Population

Table 2

Association between genotypes/alleles of miR-646 rs6513497 and the risk of HCC.

Genotypes	Controls	HCC patients			HCC patients with HBV
	Number (%)	Number (%)	OR (95% CI)^a	value^a	Number (%)	OR (95% CI)^a	value^a
miR-646 rs6513497	= 993	= 997			= 771
TT	795 (80.1)	825 (82.7)	1.000		639 (82.9)	1.000
GT	186 (18.7)	166 (16.6)	0.812 (0.635–1.037)	0.095	126 (16.3)	0.814 (0.621–1.067)	0.137
GG	12 (12.2)	6 (0.6)	0.468 (0.167–1.308)	0.147	6 (0.8)	0.631 (0.222–1.793)	0.387
Dominant model; (TT versus GT + GG)			0.791 (0.622–1.005)	0.055		0.803 (0.616–1.046)	0.104
Recessive model; (TT + GT versus GG)			0.485 (0.174–1.355)	0.168		0.654 (0.230–1.856)	0.425
T	1776 (0.9)	1816 (0.9)	1.000		1402 (91.0)	1.000
G	210 (0.1)	178 (0.1)	0.788 (0.631–0.985)	0.037*	138 (9.0)	0.814 (0.637–1.039)	0.098

^aORs and values were all obtained after adjusting for age, gender, smoking status, and wine status.
value less than 0.05.