Association between a Variant in MicroRNA-646 and the Susceptibility to Hepatocellular Carcinoma in a Large-Scale Population

Table 3

Comparison of genotype/allele frequencies of miR-646 rs6513497 in male subjects.

Genotypes	Controls	HCC patients			HCC patients with HBV
	Number (%)	Number (%)	OR (95% CI)^a	-value^a	Number (%)	OR (95% CI)^a	value^a
miR-646 rs6513497	= 721	= 819			= 643
TT	570 (79.1)	685 (83.6)	1.000		536 (83.4)	1.000
GT	143 (19.8)	129 (15.8)	0.692 (0.523–0.915)	0.010*	102 (15.9)	0.719 (0.531–0.973)	0.033*
GG	8 (1.1)	5 (0.6)	0.492 (0.151–1.596)	0.237	5 (0.7)	0.650 (0.198–2.134)	0.478
Dominant model; (TT versus GT + GG)			0.681 (0.517–0.896)	0.006*		0.715 (0.532–0.962)	0.027*
Recessive model; (TT + GT versus GG)			0.525 (0.162–1.701)	0.023*		0.690 (0.211–2.259)	0.540
T	1283 (89.0)	1499 (91.5)	1.000		1172 (91.3)	1.000
G	159 (11.0)	139 (8.5)	0.695 (0.539–0.897)	0.005*	112 (8.7)	0.739 (0.562–0.972)	0.030*

^aORs and values were obtained after the adjustment of age, gender, smoking status, and wine status.
value less than 0.05.