Association between a Variant in MicroRNA-646 and the Susceptibility to Hepatocellular Carcinoma in a Large-Scale Population

Table 4

Comparison of genotype/allele frequencies of miR-646 rs6513497 in female subjects.

Genotypes	Controls	HCC patients			HCC patients with HBV
	Number (%)	Number (%)	OR (95% CI)^a	value^a	Number (%)	OR (95% CI)^a	value^a
miR-646 rs6513497	= 272	= 178			= 128
TT	225 (82.7)	140 (78.7)	1.000		103 (80.5)	1.000
GT	43 (15.8)	37 (20.8)	1.355 (0.817–2.246)	0.239	24 (18.8)	1.318 (0.727–2.389)	0.363
GG	4 (1.5)	1 (0.5)	0.409 (0.0443–0.799)	0.431	1 (0.7)	0.597 (0.061–5.833)	0.657
Dominant model; (TT versus GT + GG)			1.274 (0.777–2.088)	0.377		1.254 (0.702–2.240)	0.444
Recessive model; (TT + GT versus GG)			0.386 (0.042–3.579)	0.402		0.568 (0.058–5.534)	0.626
T	493 (90.6)	317 (89.0)	1.000		230 (89.8)	1.000
G	51 (9.4)	39 (11.0)	1.177 (0.746–1.855)	0.484	26 (10.2)	1.183 (0.693–2.018)	0.538

^aORs and values were obtained after adjusting for age, gender, smoking status, and wine status.