Association between a Variant in MicroRNA-646 and the Susceptibility to Hepatocellular Carcinoma in a Large-Scale Population

Table 5

Clinicopathologic characteristics and genotype/allele frequencies of miR-646 rs6513497 in HCC patients.

Indexes	Genotype			value	Allele		value
Tumor size
miR-646 rs6513497	TT	GT	GG	0.713	T	G	0.617
<5 cm	180 (84.1)	35 (16.9)	0 (0)		395 (31.9)	35 (68.1)
≥5 cm	261 (82.6)	53 (16.8)	2 (0.6)		575 (34.3)	57 (65.7)
Tumor focus number
miR-646 rs6513497	TT	GT	GG	0.195	T	G	0.343
Single	396 (83.4)	78 (16.4)	1 (0.2)		870 (91.6)	80 (8.4)
Multiple	51 (79.7)	12 (18.8)	1 (1.5)		114 (89.1)	14 (10.9)
Tumor grade
miR-646 rs6513497	TT	GT	GG	0.897	T	G	0.771
I-II	71 (84.5)	13 (15.5)	0 (0)		155 (92.3)	13 (7.7)
III-IV	250 (83.1)	50 (16.6)	1 (0.3)		550 (91.4)	52 (8.6)
AFP
miR-646 rs6513497	TT	GT	GG	0.548	T	G	0.371
<20 ug/L	294 (81.0)	67 (18.5)	2 (0.6)		655 (90.2)	71 (9.8)
≥20 ug/L	511 (83.5)	97 (15.8)	4 (0.7)		1119 (91.4)	105 (8.6)
Total bilirubin
miR-646 rs6513497	TT	GT	GG	0.184
	18.79 ± 0.94	20.12 ± 3.18	21.90 ± 2.86
Direct bilirubin
miR-646 rs6513497	TT	GT	GG	0.347
	8.78 ± 0.70	9.91 ± 2.47	8.43 ± 1.32
Indirect bilirubin
miR-646 rs6513497	TT	GT	GG	0.125
	9.81 ± 0.24	10.22 ± 0.77	13.50 ± 1.78
ALT
miR-646 rs6513497	TT	GT	GG	0.643
	57.14 ± 2.79	59.92 ± 7.51	51.38 ± 8.13
AST
miR-646 rs6513497	TT	GT	GG	0.730
	62.17 ± 2.78	63.58 ± 7.04	41.50 ± 3.90
HBV-DNA
miR-646 rs6513497	TT	GT	GG	0.526