UV Spectrophotometric Simultaneous Determination of Paracetamol and Ibuprofen in Combined Tablets by Derivative and Wavelet Transforms

Table 2

Assay results for the determination of IB and PA in their combined tablets.

% of label claim (mean ± SD, 𝑛=6)
Method	Alaxan		Dibulaxan		Febro
	IB	PA	IB	PA	IB	PA
HPLC	99.4±0.9	99.8±0.9	99.8±1.3	99.4±1.0	100.3±1.0	99.3±1.2
Derivative transform
^1D spectra	99.5±0.9	100.1±1.4	100.3±1.7	99.6±1.3	99.4±0.9	99.3±1.3
^1D ratio spectra	99.8±1.3	99.1±1.1	100.2±1.5	99.3±0.9	99.4±1.5	100.1±1.4
Wavelet transform
Sym6-spectra	100.3±1.8	99.6±1.3	100.3±1.5	99.4±1.2	100.6±0.8	99.1±1.0
Haar-spectra	99.3±1.3	99.1±1.2	100.3±0.9	99.7±1.7	100.5±1.2	99.4±0.9
Mexh-spectra	101.0±1.2	100.7±0.8	100.5±1.8	98.8±1.3	99.4±0.9	99.6±1.1
Sym6-ratio spectra	100.1±1.1	99.1±1.3	99.4±0.9	100.4±0.9	99.2±1.1	99.8±0.9
Haar-ratio spectra	99.7±0.9	99.3±0.6	100.1±1.0	99.6±1.1	100.6±1.3	99.5±1.1
Derivative-Wavelet transforms combined
Sym6-^1D spectra	100.8±1.4	100.0±1.0	99.7±1.2	101.0±1.1	99.5±1.4	100.5±0.9
Haar-^1D spectra	99.5±0.8	99.5±1.0	100.7±1.1	100.9±1.3	100.7±0.8	99.8±0.8
Mexh-^1D spectra	99.7±1.0	99.5±0.9	99.8±1.3	100.2±1.5	99.7±0.9	99.8±1.2
^1D-Sym6 spectra	100.5±1.1	100.5±0.8	99.8±1.5	99.3±1.4	100.6±0.8	100.0±1.1
^1D-FWT spectra	99.9±1.4	100.4±1.3	100.1±1.3	99.9±1.2	100.4±1.1	100.4±1.0
Sym6-FWT spectra	100.7±1.1	100.3±0.9	100.4±1.1	99.7±1.4	99.6±0.9	100.1±0.9
Haar-FWT spectra	99.8±1.3	99.9±1.0	99.7±1.5	100.1±1.0	100.4±1.2	100.6±1.0
Mexh-FWT spectra	100.3±0.9	99.6±1.4	99.5±1.6	100.7±0.8	100.6±0.8	99.7±1.3