RRHGE: A Novel Approach to Classify the Estrogen Receptor Based Breast Cancer Subtypes

<table>The eight subnetworks for any training set <svg height="12.4375" id="M126" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 9.5625 12.4375" width="9.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>. In each subnetwork, the symbol “<svg height="17.0875" id="M127" style="vertical-align:-3.33061pt" version="1.1" viewbox="0 0 21.862499 17.0875" width="21.862499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,12.9)"><path d="M1059 256q0 -136 -67.5 -251t-183 -181.5t-252.5 -66.5t-252.5 66.5t-183 181.5t-67.5 251t67.5 251t183 181.5t252.5 66.5t252.5 -66.5t183 -181.5t67.5 -251zM1001 256q0 167 -109 294l-294 -294l294 -294q109 127 109 294zM851 593q-126 112 -295 112t-295 -112
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</svg>” shows the hub-gene/s, which has the highest number of interactions among other genes. In subnetwork <svg height="15.6875" id="M128" style="vertical-align:-3.39066pt" version="1.1" viewbox="0 0 14.6125 15.6875" width="14.6125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.4)"><path d="M457 488l-30 -3q-17 148 -131 148q-53 0 -84.5 -34.5t-31.5 -82.5q0 -42 25.5 -72t74.5 -62l33 -22q63 -42 95 -85t32 -102q0 -84 -67 -137t-163 -53q-58 0 -113 22t-70 43l-4 152l27 4q4 -32 15 -62.5t31 -59.5t53.5 -47t76.5 -18q56 0 92 35t36 96q0 39 -25 70t-78 68
l-31 22q-32 23 -53.5 41.5t-45 57t-23.5 77.5q0 82 58 132.5t156 50.5q46 0 101 -17l18.5 -6t17 -6t8.5 -3q-4 -55 0 -147z" id="x1D446"></path></g>
<g transform="matrix(.012,-0,0,-.012,8.225,15.475)"><path d="M137 343l67 33q37 17 63 17q79 0 129.5 -53t50.5 -131q0 -92 -58 -156.5t-147 -64.5t-147 68t-58 182q0 63 17 119t43 95.5t61.5 72t69 52t67.5 31.5q62 22 128 33l6 -32q-56 -11 -108 -35q-149 -71 -184 -231zM227 337q-47 0 -95 -27q-6 -23 -6 -70q0 -93 36 -155.5
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</svg>, two hub-genes are identified, as they both have the maximal and equal number of interactions; that is, each gene has 2 interactions.</table>

The Scientific World Journal

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Figure 1

Figure 1: RRHGE: A Novel Approach to Classify the Estrogen Receptor Based Breast Cancer Subtypes 